ABSTRACT
Introducción: La compresión medular metastásica (CMM) es una complicación severa en pacientes con cáncer cuya incidencia es difícil de estimar con exactitud. El objetivo del presente estudio es describir la incidencia, las características epidemiológicas y el pronóstico de la compresión medular metastásica en pacientes con cáncer. Material y métodos: Analizamos una cohorte con un total de 1.736 pacientes con diagnóstico de cáncer de cualquier origen ingresados en una unidad de cuidados paliativos. De los pacientes con diagnóstico de CMM, se recogieron datos epidemiológicos, signos y síntomas, tiempo medio hasta el diagnóstico, régimen de tratamiento, respuesta al tratamiento y mortalidad. Resultados: De un total de 1.736 pacientes, se identificaron 28 (1,6%) casos de CMM. La edad promedio fue de 67,2 (DE: 12,7) años siendo el cáncer de pulmón el tumor primario más frecuente (42,8%). La columna torácica fue la localización más afectada (42,8%; n=12) y el dolor el síntoma predominante (46,4%, n=13). La mediana de supervivencia después del diagnóstico de CMM fue de 84,5 días. Conclusiones: Hemos obtenido una incidencia del 1,6% (N=28) de CMM en una cohorte de 1.736 pacientes con cáncer. La CMM es un marcador de mal pronóstico con una supervivencia media menor de 3 meses desde el diagnóstico y una mortalidad intrahospitalaria del 32,4%
Background: Metastatic spinal cord compression (MSCC) is a severe complication in patients with cancer, and its incidence rate is difficult to accurately estimate. The aim of this study is to report the incidence and epidemiological and prognostic characteristics of MSCC in patients with cancer. Material and methods: We analysed a cohort of 1736 patients diagnosed with cancer of any origin who were hospitalised in a palliative care unit. We collected epidemiological data, signs and symptoms, mean time to diagnosis, treatment regimen, response to treatment and mortality for the patients diagnosed with MSCC. Results: In the 1736 patients, we identified 28 (1.6%) cases of MSCC. The average age was 67.2 (SD, 12.7) years, and lung cancer was the most common primary tumour (42.8%). The thoracic spine was the most affected location (12 cases, 42.8%), and pain was the predominant symptom (13 cases, 46.4%). The median survival after the MSCC diagnosis was 84.5 days. Conclusions: We observed an incidence rate of 1.6% (N=28) for MSCC in a cohort of 1736 patients with cancer. MSCC is a marker of poor prognosis, with a mean survival of less than 3 months from diagnosis and a hospital mortality of 32.4%
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Spinal Cord Compression/epidemiology , Neoplasms/complications , Neoplasm Metastasis/pathology , Hospital Mortality , Biomarkers, Tumor/analysis , Incidence , Prognosis , Retrospective StudiesABSTRACT
BACKGROUND: Metastatic spinal cord compression (MSCC) is a severe complication in patients with cancer, and its incidence rate is difficult to accurately estimate. The aim of this study is to report the incidence and epidemiological and prognostic characteristics of MSCC in patients with cancer. MATERIAL AND METHODS: We analysed a cohort of 1736 patients diagnosed with cancer of any origin who were hospitalised in a palliative care unit. We collected epidemiological data, signs and symptoms, mean time to diagnosis, treatment regimen, response to treatment and mortality for the patients diagnosed with MSCC. RESULTS: In the 1736 patients, we identified 28 (1.6%) cases of MSCC. The average age was 67.2 (SD, 12.7) years, and lung cancer was the most common primary tumour (42.8%). The thoracic spine was the most affected location (12 cases, 42.8%), and pain was the predominant symptom (13 cases, 46.4%). The median survival after the MSCC diagnosis was 84.5 days. CONCLUSIONS: We observed an incidence rate of 1.6% (N=28) for MSCC in a cohort of 1736 patients with cancer. MSCC is a marker of poor prognosis, with a mean survival of less than 3 months from diagnosis and a hospital mortality of 32.4%.
