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Emerg Microbes Infect ; 9(1): 889-899, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32284015

ABSTRACT

In the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 Brucella strains containing 4 biotypes were obtained, including Brucella melitensis bv.1 (n = 8) and bv.3 (n = 106), Brucella abortus bv.3 (n = 3) and bv.7 (n = 1). Twenty-one shared MLVA-16 genotypes, each composed of 2 to 19 strains obtained from different hosts, suggest the occurrence of a brucellosis outbreak epidemic with multiple source points and laboratory infection events. Moreover, 30 shared MLVA-16 genotypes were observed among 59.6% (68/114) B. melitensis isolates from Zhejiang and strains from other 21 different provinces, especially northern provinces, China. The analysis highlighted the imported nature of the strains from all over the northern provinces with a dominant part from the developed areas of animal husbandry. These data revealed a potential transmission pattern of brucellosis in this region, due to introduced infected sheep leading to a brucellosis outbreak epidemic, and eventually causing multiple laboratory infection events. It is urgent to strengthen the inspection and quarantine of the introduced animals.


Subject(s)
Brucella/classification , Brucellosis/epidemiology , Brucellosis/transmission , Laboratory Infection/microbiology , Sheep/microbiology , Animals , Bacterial Typing Techniques , Brucella abortus/genetics , Brucella melitensis/genetics , China/epidemiology , DNA, Bacterial/genetics , Disease Outbreaks , Genetic Variation , Genotype , Humans , Minisatellite Repeats , Multilocus Sequence Typing , Phylogeny , Seroepidemiologic Studies
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