ABSTRACT
Investigation of the non-ohmic transport behaviors under high magnetic fields can provide a new way to explore novel field-induced phenomena. We present the current-voltage measurements under high magnetic fields based on the flat-top pulsed magnetic field system. Two different measurement strategies were compared, given that the excitation current swept continuously or increased by a series of pulses. For the short duration of the flat-top pulsed field, the continuous current method was adopted and well optimized to reduce the Joule heating and achieve the quasi-static measurements. Finally, the non-ohmic behaviors of a quasi-one-dimensional charge density wave Li0.9Mo6O17 were successfully studied under the magnetic field up to 30 T at 4.2 K, which was the first current-voltage measurements carried out in pulsed magnetic fields.
ABSTRACT
Minocycline is a type of tetracycline antibiotic with broad-spectrum antibacterial activity that has been demonstrated to protect the brain against a series of central nervous system diseases. However, the precise mechanisms of these neuroprotective actions remain unknown. In the present study, we found that minocycline treatment significantly reduced HT22 cell apoptosis in a mechanical cell injury model. In addition, terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining confirmed the neuroprotective effects of minocycline in vivo through the inhibition of apoptosis in a rat model of controlled cortical impact (CCI) brain injury. The western blotting analysis revealed that minocycline treatment significantly downregulated the pro-apoptotic proteins BAX and cleaved caspase-3 and upregulated the anti-apoptotic protein BCL-2. Furthermore, the beam-walking test showed that the administration of minocycline ameliorated traumatic brain injury (TBI)-induced deficits in motor function. Taken together, these findings suggested that minocycline attenuated neuronal apoptosis and improved motor function following TBI.
