ABSTRACT
We investigated the clinical efficacy of propranolol in treating proliferating infantile haemangiomas, and the serological changes in vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) during treatment. Propranolol was given orally to 35 infants with proliferating haemangiomas in a dose of 1.0-1.5mg/kg/day. Hemisphere measurements, the 4-score method, and feedback from parents were used to evaluate the clinical curative effects. An ELISA was used to measure the serum concentrations of VEGF and eNOS before, and 1 and 2 months after, treatment. The response was excellent in 6 patients, good in 16, moderate in 10, and poor in 3. The peripheral serum concentrations of VEGF and eNOS 2 months after treatment were significantly lower than those before treatment (p<0.01). We conclude that propranolol can be safely and effectively used to treat proliferating infantile haemangiomas. It can reduce the peripheral serum concentrations of VEGF and eNOS in affected children.
Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Endothelium, Vascular/drug effects , Head and Neck Neoplasms/drug therapy , Hemangioma/drug therapy , Nitric Oxide Synthase/blood , Propranolol/therapeutic use , Vascular Endothelial Growth Factor A/blood , Administration, Oral , Analysis of Variance , Endothelium, Vascular/metabolism , Enzyme-Linked Immunosorbent Assay , Female , Humans , Infant , Male , Treatment OutcomeABSTRACT
OBJECTIVE: To investigate the clinical effect of electrochemical therapy (ECT) combined with pingyangmycin (PYM) injection for the treatment of high-return flow venous malformation. METHODS: A total of 68 cases of the high-return flow venous malformation were retrospectively analyzed, in which 32 cases received simplely ECT,and 36 cases received ECT combined with PYM injection. The patients were followed up from 6 to 30 months. RESULTS: The effectiveness of ECT was 78% (25/32), and of ECT combined with PYM injection was 97% (35/36). The effectiveness of ECT combined with PYM injection was higher than that of ECT (P < 0.05). No serious adverse effects were encountered. CONCLUSIONS: ECT combined with PYM injection is an effective method for the treatment of high-return flow venous malformation.
Subject(s)
Bleomycin/analogs & derivatives , Electrochemical Techniques/methods , Vascular Malformations/therapy , Veins/abnormalities , Adolescent , Adult , Aged , Bleomycin/administration & dosage , Bleomycin/therapeutic use , Blood Flow Velocity , Child , Child, Preschool , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Injections , Male , Middle Aged , Retrospective Studies , Vascular Malformations/drug therapy , Vascular Malformations/physiopathology , Young AdultABSTRACT
BACKGROUND: The lip carcinoma, which frequently affects the lower lip, is one of the most common cancers of the head and neck region composing 25% to 30% of all oral cancers. The accepted method of therapy for lip cancer is surgical excision and reconstruction. The repair should satisfy 2 fundamental requirements: to achieve appropriate aesthetic quality and to conserve labial function. Currently, a wide range of reconstructive procedures have been developed. OBJECTIVE: The objective of the study was to summarize the clinical experience of reconstruction for lower lip defects to facilitate the selection of a proper reconstructive strategy for different conditions in clinical practice. METHODS: We performed a retrospective analysis of 43 patients who had undergone a standardized reconstructive approach based on the literature published and our own experience over the past 4 years. RESULTS: Over an average period of 7.5 months' follow-up, recurrences or major complications did not happen, and most patients were satisfied with their functional and aesthetical outcome. Focusing on the location and the width of the defects of lower lip, a table has been exhibited to orient the surgeons to select a suitable reconstructive procedure for each patient. CONCLUSIONS: Successful reconstruction of all defects can be attained, if as many surgical procedures as possible have been mastered, and a more proper means used.
