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1.
J Biochem ; 171(4): 451-457, 2022 Mar 31.
Article in English | MEDLINE | ID: mdl-35106560

ABSTRACT

MicroRNA plays a crucial part in genesis and development of gastric cancer (GC). We uncovered that microRNA-30c-2-3p was down-regulated in GC tissue and cell lines. Suppression of microRNA-30c-2-3p promoted progression of GC cells in vitro. STRIP2 was confirmed as a target for microRNA-30c-2-3p. MicroRNA-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of STRIP2 partially restored the anticancer effect of microRNA-30c-2-3p. Taken together, these findings suggested that microRNA-30c-2-3p acted as a candidate tumour suppressor in GC by directly targeting STRIP2. Therefore, microRNA-30c-2-3p can be used as a towardly GC therapeutic target.


Subject(s)
MicroRNAs , Stomach Neoplasms , Cell Line, Tumor , Cell Proliferation/genetics , Gene Expression Regulation, Neoplastic , Humans , MicroRNAs/genetics , MicroRNAs/metabolism , Stomach Neoplasms/metabolism
2.
J Hazard Mater ; 353: 151-157, 2018 07 05.
Article in English | MEDLINE | ID: mdl-29660701

ABSTRACT

Reduced graphite oxide (rGO) was incorporated into a metal organic framework (MOF) MIL-101(Cr) for the modification of carbon paste electrode. Taking advantages of the large surface area of MOF and the electrical conductivity of rGO, the resulted electrodes exhibited high sensitivity and reliability in the simultaneous electrochemical identification and quantification of catechol (CC) and hydroquinone (HQ). Specifically, in the mixture solution of catechol and hydroquinone (constant concentration of an analyte), the linear response ranges for catechol and hydroquinone were 10-1400 µM and 4-1000 µM, and detection limits were 4 µM and 0.66 µM (S/N = 3) for individual catechol and hydroquinone, respectively. Therefore, the relatively easy fabrication of modified CPE and its fascinating reliability towards HQ and CC detection may simulate more research interest in the applications of MIL-101(Cr)-rGO composites for electrochemical sensors.

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