ABSTRACT
<p><b>OBJECTIVE</b>To investigate the change of Th17/Treg cell in patients with psoriasis arthritis (PA) and its clinical significance.</p><p><b>METHODS</b>The levels of IL-17 and TGF-β1 were measured by enzyme-linked immunosorbent assay(ELISA) in PA patients (n=35) and healthy controls(n=30). The frequencies of Th17 and Treg in the peripheral blood were detected by flow cytometry.</p><p><b>RESULTS</b>Compared with the healthy controls, Th17/Treg in peripheral blood were significantly increased (p<0.05), Th17-related cytokine IL-17 significantly increased (p<0.05), and TGF-β1 significantly decreased (p<0.05) in the PA patients.</p><p><b>CONCLUSION</b>Th17/Treg cell and the related cytokines IL-17 and TGF-β1 may be involved in the pathogenesis of PA.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Arthritis, Psoriatic , Blood , Allergy and Immunology , Case-Control Studies , Interleukin-17 , Blood , T-Lymphocytes, Regulatory , Allergy and Immunology , Th17 Cells , Allergy and Immunology , Transforming Growth Factor beta1 , BloodABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of human beta-defensin-2 (HBD-2) mRNA in skin lesions of patients with recurrent genital herpes (RGH) and the effect of Huangbai Liquid (HL) on it.</p><p><b>METHODS</b>Twenty-seven patients were randomly assigned to 2 groups, the HL group (n = 14) treated with HL and the famciclovir group (n = 13) with famciclovir. HBD-2 expression of patients were detected before and after the treatment and compared with that of 10 healthy subjects.</p><p><b>RESULTS</b>HBD-2 expression was found in the skin lesions of both the healthy persons and the RGH patients before treatment. It is higher significantly in the HL group than in the famciclovir group after treatment.</p><p><b>CONCLUSION</b>HL was suitable for treatment of RGH since it could improve immune function of RGH patients and keep a rather higher concentration of HBD-2 expression in local skin lesions.</p>
