Efficient photocatalytic hydrogen peroxide production over S-scheme In2S3/molten salt modified C3N5 heterojunction.

Graphitic phase carbon nitride (g-C3N5), as a novel n-type metal-free material, is employed as a visible light-receptive catalyst because of its narrow band gap and abundant nitrogen. To overcome the low carrier mobility efficiency of g-C3N5, its modification by K ions was adopted. In addition, In2S3 was selected to couple with modified g-C3N5 to overcome the recombination of photogenerated e-/h+. As a novel photocatalytic material, it was proven to possess a high visible light absorption capacity and a strong H2O2 production ability (up to 3.89 mmol⋅L-1 in 2 h). Moreover, a S-scheme heterojunction structure was successfully constructed between the two materials, which was tested and confirmed to be successful in raising the photogenerated e-/h+ separation efficiency. Ultimately, the primary processes of photocatalytic H2O2 production were summarized by superoxide radical and rotating disc electron measurements. This research provides a fresh perspective for the synthesis of C3N5-based S-scheme heterojunction photocatalysts for producing H2O2.

Effect and mechanism of microRNAs on various diabetic wound local cells.

The difficulty of wound healing in diabetes mellitus has long been regarded as a thorny problem in the medical field. One of the important reasons is the abnormal function of wound-related cells. A large number of recent studies have shown that microRNA (miR), a noncoding RNA that exists in eukaryotic cells, is closely linked to the functions of various cells in diabetic wound, and ultimately affects the healing of wound. This paper establishes for the first time the connection between miR and wound healing from the cellular perspective and summarizes the effects of various miRs on one or more kinds of wound cells, including their targets and related mechanisms. The abnormal expression of miRs in the wound has certain value for the early diagnosis of diabetic wounds. Moreover, it seems that correcting miRs that are abnormal expressed in the wound or artificially adding miRs that can promote wound healing has an essential therapeutic value.

Efficient Photocatalytic H2 O2 Production Ability of a Novel Graphitic Carbon Nitride/Carbon Composites under Visible Light.

In the present work, using one-step calcination of a mixture made of potassium hydroxide (KOH), melamine, and microplastics, this work prepares a novel graphitic carbon nitride/carbon (g-C3 N4 /C) composite, which can be employed to photo-catalytically produce hydrogen peroxide (H2 O2 ) at a high rate up to 6.146 mmol g-1 h-1 under visible light irradiation. By analyzing the energy band structure of the catalyst, the production of H2 O2 in this system consists of two single-electron reactions. The modification of KOH makes abundant N-vacancies caused by cyano-groups in g-C3 N4 , enhancing the electron absorption ability. Moreover, the introduction of graphitic carbon increases its specific surface area and porosity and improves the adsorption ability of O2 . Simultaneously, their synergism reduces the g-C3 N4 band gap, making both the conduction-band and valence-band positions more negative, showing enhanced reduction ability, lowering the energy barrier for oxygen reduction, and greatly improving the photogeneration performance of H2 O2 .

Mesenchymal Stem Cell Derived Exosomes Therapy in Diabetic Wound Repair.

Nowadays, refractory diabetic wounds cause a worldwide medical burden. Mesenchymal stem cells derived exosomes (MSC-Exos) show promise as a solid alternative to existing therapeutics in the latest researches, since MSC-Exos share similar biologic activity but less immunogenicity when compared with MSCs. To facilitate further understanding and application, it is essential to summarize the current progress and limitations of MSC-Exos in the treatment of diabetic wounds. In this review, we introduce the effects of different MSC-Exos on diabetic wounds according to their origins and contents and discuss the specific experimental conditions, target wound cells/pathways, and specific mechanisms. In addition, this paper focuses on the combination of MSC-Exos and biomaterials, which improves the efficacy and utilization of MSC-Exos therapy. Together, exosome therapy has high clinical value and application prospects, both in its role and in combination with biomaterials, while novel drugs or molecules loaded into exosomes as carriers targeting wound cells will be development trends.

Preparation and characterization of novel Niln2S4/UiO-66 photocatalysts for the efficient degradation of antibiotics in water.

Photocatalysis is considered an economical, environmentally friendly, and effective technology for removing pollutants. The construction of Z-Scheme heterojunctions has been identified as one of the feasible solutions capable of enhancing the photocatalytic activity. Herein, a series of visible light responsive photocatalysts (NiIn2S4/UiO-66 composites) with excellent activity and stability were prepared by using a solvothermal process. It is found that 20 mg L-1 of tetracycline (TC) could be almost completely degraded under visible light irradiation within 1 h, when the mass ratio of NiIn2S4 to UiO-66 is 0.5:1 (NISU-0.5) and the solution pH = 11. In addition, after six cycles, the degradation rate of tetracycline photocatalyzed by NISU-0.5 still reach up to 90%. Ultraviolet photoelectron spectra (UPS), X-ray photoelectron spectra (XPS) and electron spin resonance measurements (ESR) confirm the formation of the Z-Scheme heterostructure between NiIn2S4 and UiO-66. The synergistic effect between built-in electric field, energy band bending and coulomb interactions in interface of Z-Scheme heterojunction is conducive to restrain the recombination of photogenerated electrons and holes, which greatly improve the photocatalytic activity. In conclusion, this study offers a new thought for design and synthesis of Z-Scheme heterojunctions and provides a cost-effective strategy for solving environmental pollution and energy problems in the future.

RNA adenosine modifications related to prognosis and immune infiltration in osteosarcoma.

BACKGROUND: RNA adenosine modifications, which are primarily mediated by "writer" enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression and prognostic role of these genes in osteosarcoma (OS) remain unclear. METHODS: Univariate and multivariate Cox analyses were used to construct the RMW signature for OS using Target datasets. RMW expression in OS tissue was detected by qPCR analysis. Xcell and GSVA were used to determine the relationship between RMWs and immune infiltration. The DGIdb and CMap databases were used for drug prediction. In vivo and in vitro experiments showed that strophanthidin elicited antitumor activity against OS. RESULTS: A 3-RMW (CSTF2, ADAR and WTAP) prognostic signature in OS was constructed using the Target dataset and verified using GEO datasets and 63 independent OS tissues via qPCR analysis. High-risk OS patients had poor overall survival, and the prognostic signature was an independent prognostic factor for OS. Functional studies showed that tumour-, metabolism-, cell cycle- and immune-related pathways were related to high risk. Next, we found that RMW-derived high-risk patients exhibited increased infiltration of M2 macrophages and cDCs. Furthermore, we predicted the potential drugs for OS using the DGIdb and CMap databases. In vivo and in vitro experiments showed that strophanthidin elicited antitumor activity against OS by repressing cell growth and inducing cell cycle arrest at the G1 phase. CONCLUSION: The 3-RWM-based prognostic signature established in this study is a novel gene signature associated with immune infiltration, and strophanthidin was identified as a candidate therapy for OS by repressing OS cell growth and the cell cycle.

Self-standing heterostructured NiC x -NiFe-NC/biochar as a highly efficient cathode for lithium-oxygen batteries.

Lithium-oxygen batteries have attracted research attention due to their low cost and high theoretical capacity. Developing inexpensive and highly efficient cathode materials without using noble metal-based catalysts is highly desirable for practical applications in lithium-oxygen batteries. Herein, a heterostructure of NiFe and NiC x inside of N-doped carbon (NiC x -NiFe-NC) derived from bimetallic Prussian blue supported on biochar was developed as a novel self-standing cathode for lithium-oxygen batteries. The specific discharge capacity of the best sample was 27.14 mAh·cm-2 at a stable discharge voltage of 2.75 V. The hybridization between the d-orbital of Ni and s and p-orbitals of carbon in NiC x , formed at 900 °C, enhanced the electrocatalytic performance due to the synergistic effect between these components. The structure of NiC x -NiFe-NC efficiently improved the electron and ion transfer between the cathode and the electrolyte during the electrochemical processes, resulting in superior electrocatalytic properties in lithium-oxygen batteries. This study indicates that nickel carbide supported on N-doped carbon is a promising cathode material for lithium-oxygen batteries.

Carbon-Encapsulated WOx Hybrids as Efficient Catalysts for Hydrogen Evolution.

Developing non-noble metal catalysts as Pt substitutes, with good activity and stability, remains a great challenge for cost-effective electrochemical evolution of hydrogen. Herein, carbon-encapsulated WOx anchored on a carbon support (WOx @C/C) that has remarkable Pt-like catalytic behavior for the hydrogen evolution reaction (HER) is reported. Theoretical calculations reveal that carbon encapsulation improves the conductivity, acting as an electron acceptor/donor, and also modifies the Gibbs free energy of H* values for different adsorption sites (carbon atoms over the W atom, O atom, WO bond, and hollow sites). Experimental results confirm that WOx @C/C obtained at 900 °C with 40 wt% metal loading has excellent HER activity regarding its Tafel slope and overpotential at 10 and 60 mA cm-2 , and also has outstanding stability at -50 mV for 18 h. Overall, the results and facile synthesis method offer an exciting avenue for the design of cost-effective catalysts for scalable hydrogen generation.

[Identification and classification of textiles based on terahertz time domain spectroscopy].

A method to discriminate textiles was proposed based on terahertz time-domain spectroscopy (THz-TDS) and clustering analysis, and some typical cotton textiles were investigated to prove its feasibility. Their time domain waveforms were measured using THz-TDS system and then their absorption spectra were obtained. Principal component analysis (PCA) was applied to extract features of the data, and then Mahalanobis distance discriminant method was employed to classify these materials. The results show that this method can classify these five textiles accurately. It indicates that the method to classify textiles is feasible which combines PCA and Mahalanobis distance discriminant method based on their THz absorption spectra. The proposed method has a potential for identifying textiles of similar composition.

Enhanced Raman scattering as a probe for 4-mercaptopyridine surface-modified copper oxide nanocrystals.

We report on the application of Raman scattering as a probe to study 4-mercaptopyridine (4-Mpy) surface-modified CuO nanocrystals. Enhanced Raman scattering from 4-Mpy adsorbed on CuO nanocrystals was observed. The Raman signals displayed 10(2) enhancement compared with those of 4-Mpy in solution. We compared the Raman spectra of 4-Mpy molecules adsorbed on CuO nanocrystals and Ag, Cu substrate. A particular feature of the semiconductor substrate that was different from the metal substrate was revealed. The excitation wavelength-dependent behavior was clearly observed.