ABSTRACT
OBJECTIVE: To investigate the changes of tooth pain in patients with orthodontic tooth movement, to study the changes of bioactivators in GCF in patients with orthodontic tooth movement, and explore the correlation between pain and bioactivators in orthodontic patients. METHODS: 50 patients were included, each having one treatment tooth and one contralateral control tooth. The levels of PGE(2), P substances, IL-6 and GM-CSF in GCF of upper lateral incisor were investigated before activation and at 12th hour, 24th hour, 48th hour and 72th hour after the applying labial orthodontic force, by using highly sensitive radioimmunassay. To record the changes of pain in orthodontic patients at 12th hour, 24th hour,48th hour and 72th hour after applying stress. RESULTS: At experimental sides, total amount of GCF PGE(2), P substances(SP), IL-6 and GM-CSF levels was significantly elevated compared with that before activation. The concentration of PGE(2) and SP in GCF increased significantly and reached peak point at 24th hour in patients, while the levels of IL-6 and GM-CSF in GCF remained at higher baseline through the experiment. There was an rhythm change of periodontal pain during orthodontic tooth movement. CONCLUSION: There was an rhythm changes of pain after stress in patients with orthodontic tooth movement, and the rhythm pain was correlated to the changes of some activator such as P substances and PGE(2) in periodontal ligament.
