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1.
Chinese Journal of Neuromedicine ; (12): 692-696, 2017.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-1034620

ABSTRACT

Objective To explore the association between inducible nitric oxide synthase (iNOS) gene polymorphisms and ischemic stroke in Uygur population of Xinjiang.Methods A case-control study was performed,included 316 patients with ischemic stroke,admitted to our hospital from June 2007 to December 2013,and 316 age-and gender-matched healthy subjects in Uygur population of Hami.The genotypes ofrs2779248(C/T) and rs1137933(C/T) were determined by Taqman probe fluorescent quantitative PCR.Results The distribution frequencies of rs2779248 (CC,CT and TT) were 51.9%,42.1% and 6.0% in the patient group,ands 61.7%,30.1% and 8.2% in the controls,respectively.As compared with those with rs2779248 CC genotype,individuals with CT+TT genotype and CT genotype had higher risk ofischemic stroke,the odds ratio was 1.49 (95%CI:1.09-2.05,P=0.013)and 1.66 (95%CI:1.19-2.32,P=0.003).The distribution frequencies ofrs1137933 (CC,CT and TT) were 66.8%,28.5% and 4.7% in the patient group,ands 66.8%,27.8% and 5.4% in the controls,respectively;no significant difference was noted between the patient group and controls in the distribution frequencies (P>0.05).Multi-factor Logistic regression analysis indicated that mutation of genotype C>T in rs2779248was the independent risk factor of ischemic stroke in Uygur population of Hami after adjusting related risk factors (OR=1.55,95%CI:1.00-2.40,P=0.049).Conclusion The polymorphisms ofrs2779248 in iNOS gene may modify the risk of ischemic stroke in Uygur population of Hami,but no association is found in rs1137933.

2.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-490386

ABSTRACT

Objective To investigate the correlation between inducible nitric oxide synthase (iNOS) gene polymorphism and ischemic stroke in Chinese Han population.Methods Patients with first-ever stroke and the age-and sex-matched healthy controls were enrolled in the study.Taqman probe fluorescence quantitative polymerase chain reaction technique was used to detect the genotype distribution of rs2779248 C/T and rs1137933 C/T polymorphisms.Results A total of 246 patients with ischemic stroke and 246 controls were enrolled.The distribution frequencies of rs2779248 CC,CT and TT genotypes in the patient group were 57.7%,36.6%,and 5.7%,respectively,and in the control group were 68.7%,28.0%,and 3.3%,respectively.The T allele frequency of the patient group was significantly higher than that of the control group (24.0% vs.17.3%;P =0.015).Multivariate logistic regression analysis showed that after adjusting for the risk factors including age,sex,hypertension,and diabetes,the risk of ischemic stroke in the CT + TT genotype carriers was 1.64 times of the CC genotype carriers (odds ratio 1.64,95% confidence interval 1.07-2.51;P=0.022).The distribution frequencies of rs1137933 CC,CT and TT in the patient group were 58.1%,37.8%,and 4.1%,respectively and in the control group were 68.3%,29.3%,and 2.4%,respectively.The T allele frequency of the patient group was significantly higher than that of the control group (23.0% vs.17.1%;P =0.013).Multivariate logistic regression analysis showed that after adjusting for traditional risk factors,the risk of ischemic stroke of patients with the TT + CT genotype carriers was 1.60 times of the CC genotype carriers (odds ratio 1.60,95% confidence interval 1.05-2.46;P=0.030).Conclusions The rs2779248 C/T and rs1137933 C/T polymorphisms in iNOS gene may be associated with the risk of onset of ischemic stroke in Chinese Han population.

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