ABSTRACT
Objective To study the clinical significance of serum cystatin C (Cys C) in patients with acute leukemia (AL). Methods A total of 59 newly diagnosed AL patients in Xinghua City People's Hospital from January 2014 to August 2017 were enrolled; meanwhile, 59 healthy individuals who underwent physical examination at Medical Center of Xinghua City People's Hospital were selected as the control group. AU5800 automatic biochemical analyzer from American Beckman Coulter Corporation was applied to detect the levels of serum Cys C, lactate dehydrogenase (LDH) and creatinine (Cr). The receiver operating characteristic (ROC) curve was also drawn. Results The levels of serum Cys C and LDH in AL patients were higher than those in the control group [serum Cys C: (1.36±0.72) mg/L vs. (0.76±0.27) mg/L; LDH: (456±362) U/L vs. (185±29) U/L], and there was a statistical significance (t＝-5.965, P＝0.000; t＝-5.718, P＝0.000). There was no statistical difference in the serum Cr between AL patients and control group [(86±26) μmol/L vs. (82±16) μmol/L] (P＞ 0.05). There was a positive correlation between levels of serum Cys C and LDH in AL patients (rs＝ 0.447, P < 0.05). The ROC area under curve of serum Cys C was 0.823, the standard error was 0.037, and the confidence interval of 95 % was 0.751-0.896. The ROC area under curve of serum LDH was 0.811, the standard error was 0.042, and the confidence interval of 95 % was 0.728-0.894. Conclusion The level of serum Cys C in AL patients is higher than that in the healthy population. The detection of serum Cys C is helpful in the diagnosis of AL and the evaluation of tumor burden, which is consistent with serum LDH.
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OBJECTIVE@#To analyse the effect of low intensity pulsed ultrasound stimulation (LIPUS) on accelerating the fibrocartilage layer repair of patella-patellar tendon junction.@*METHODS@#A total of 60 mature female New Zealand white rabbits undergoing standard partial patellectomy were divided into 2 groups randomly. The control group was given comfort treatment and the treatment group was given LIPUS treatment starting from day 3 to the end of week 6 postoperatively. The scheduled time points of animal euthanization would be at week 6, week 12 and week 18 postoperatively. The patella-patellar tendon (PPT) complex would be harvested and cut into sections after decalcification for H&E staining, Safranine o/fast green staining. The thickness and gray value of fibrocartilage layer were analyzed by SANO Microscope Partner image analyzer.@*RESULTS@#At week 6, week 12 and week 18 postoperatively, the fibrocartilage layer in the treatment group was significantly thicker than that in the control group (P<0.01), and the gray value of fibrocartilage layer was significantly smaller than that in the control group (P<0.01).@*CONCLUSION@#LIPUS helps to accelerate the fibrocartilage layer repair of patella-patellar tendon junction in rabbit models.
Subject(s)
Animals , Female , Rabbits , Fibrocartilage , Pathology , Patella , General Surgery , Patellar Ligament , Wounds and Injuries , Pathology , General Surgery , Tendon Injuries , Therapeutics , Ultrasonic Therapy , Methods , Wound Healing , PhysiologyABSTRACT
Objective To summarize the types and reasons of misdiagnosis in multiple myeloma (MM),and the approaches of avoiding misdiagnosis by analyzing the misdiagnosis data in MM.Methods 197 references of misdiagnosed MM were retrieved from Wanfang medicine net by using the key words multiple myeloma and misdiagnosis from the year 2000 to 2012,and 62 of them with complete data and statistical certainty from level 2 or higher national hospitals were analyzed and summarized.Results In 62 references,2110 patients were misdiagnosis.There were more than 160 misdiagnosed MM.The shortest time of delay in diagnosis was one week,and the longest was tcn years.The rate of misdiagnosis in MM was 56.44 ％ (1406/2491).The onset age of the youngest was 16 years old and the oldest was 87 years old.A difference of nearly 20 years was found between the maximum and minimum average age of onset.MM was misdiagnosed as 10 kinds of diseases.They were including bone joint disease 32.23 ％ (680/2110),other blood diseases 11.75 ％ (248/2110),infection 14.5 ％ (306/2110),solid tumor 6.35 ％ (134/2110),kidney disease 18.58 ％ (392/2110),digestive system disease 3.13 ％ (66/2110),rheumatism 4.64 ％ (98/2110),heart disease 4.64 ％ (57/2110),nervous system disease 2.99 ％ (63/2110),endocrine disease 0.38 ％ (8/2110).Conclusion MM could occur in all ages except children and may be mistaken for a variety of diseases.It is key to prevent misdiagnosis by strengthening the comprehensive understanding of MM by taking detailed history,careful physical examination,comprehensive laboratory examination,and comprehensive clinical thinking.
