ABSTRACT
Kidney is a highly vascularized organ and peritubular capillary network constitutes the critical component of its microvascular system. Peritubular capillaries, as the main vessels for blood supply in renal tubules and renal interstitium, involve in important physiological processes in renal tubules such as energy metabolism, substance secretion and reabsorption. In recent years, it has been demonstrated that ischemia-reperfusion injury, rejection and renal fibrosis during kidney transplantation would result in compromised structural integrity and decreased number in peritubular capillaries, thus leading to interstitial fibrosis in renal allograft, which would seriously affect the long-term stability of renal function in the renal allograft. Therefore, we reviewed the structure and function of peritubular capillary, peritubular capillary and ischemia-reperfusion injury, rejection and renal allograft fibrosis, focusing on the mechanism for peritubular capillary injury in kidney transplantation and the specific changes manifested, with the aim of providing a reference for preventing and treating perioperative complications in kidney transplantation and improving the long-term prognosis of grafts.
ABSTRACT
OBJECTIVE: Previous studies on the association between extracorporeal shock wave lithotripsy (SWL) and new onset hypertension have only illustrated contradictory results. In order to illustrate the association between SWL and new onset hypertension, a meta-analysis of case-control and cohort studies was conducted. METHODS: Relevant literature was searched using PubMed, EMBASE, and the Cochrane Central Search Library. A meta-analysis of the association between SWL and new onset hypertension was performed. Studies were pooled, and summary relative risk was calculated. Subgroup analyses were also conducted. RESULTS: Eleven studies were eligible for our analysis. No statistical significance was detected between SWL and new onset hypertension (RR = 1.06, 95 % CI 0.83-1.35). No association was observed when stratified analyses were performed on age, gender, study design, bilateral SWL, and different machines. CONCLUSION: Our analysis indicated that no association was found between SWL and the development of hypertension.
