ABSTRACT
Ectopic (extradural) meningiomas that do not originate from either the optic fascicle or the intracranial meninges are exceedingly rare. A patient with an ectopic meningioma in the external auditory canal and mastoid was treated in our unit. The world literature of the last 20 years was reviewed.
Subject(s)
Ear Neoplasms/diagnosis , Meningioma/diagnosis , Audiometry, Pure-Tone , Ear Canal , Ear Neoplasms/surgery , Humans , Male , Meningioma/surgery , Middle Aged , Tomography, X-Ray ComputedABSTRACT
Sickle cell/haemoglobin D-Punjab disease is a disorder with similar clinical features to sickle cell anaemia. This report describes the case of an 11 year old boy with this disease who was treated with regular transfusions from infancy. He underwent splenectomy at the age of 10 years for hypersplenism. Histology of the spleen revealed a striking pattern of heavy sinusoidal endothelial iron loading, with only moderate uptake by macrophages. Possible explanations for this unusual distribution of iron include phagocytosis of sickled erythrocytes by sinusoidal endothelial cells or direct endothelial iron uptake via transferrin receptors. Transfusion programmes ameliorate the symptoms of sickle cell disease but the dangers of iron overload should always be remembered.
Subject(s)
Anemia, Sickle Cell/complications , Hemoglobins, Abnormal/analysis , Iron Overload/etiology , Anemia, Sickle Cell/therapy , Child, Preschool , Humans , Iron Overload/pathology , Male , Spleen/pathology , Transfusion ReactionABSTRACT
A report of an asymptomatic cardiac hemangioma in a middle-aged man is presented. This is followed by a literature review of mediastinal hemangiomas.
