Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single-blinded trial.

OBJECTIVES: Calcium alginate is a biodegradable gel-transforming agent widely used for nasal packing. It can reduce pain and improve comfort. However, few randomised controlled trials have compared the efficacy of calcium alginate nasal packing with that of other biodegradable gel-transforming materials. DESIGN: Prospective, randomised, single-blinded controlled study. SETTING: Yonsei University Severance Hospital, a tertiary academic medical centre. PARTICIPANTS: Twenty-seven patients (54 nostrils) with chronic rhinosinusitis who were scheduled for bilateral endoscopic sinus surgery were enrolled. After surgery, one nostril was packed with calcium alginate and the other with carboxymethyl cellulose. Only patients with an intersinus chronic rhinosinusitis severity score difference of ≤1 were included. MAIN OUTCOME MEASURES: Visual analogue scale (VAS) scores for postoperative pain, discomfort from nasal discharge and pain during packing removal were analysed. Two independent rhinologists who were blinded to the assessments separately scored adhesions, oedema and infection by endoscopic digital photography at 1, 4 and 8 weeks postoperatively. RESULTS: There were no significant differences in VAS scores for postoperative pain, discomfort from nasal discharge or pain during packing removal between calcium alginate packings and carboxymethyl cellulose packings. Inter-rater variability of adhesion, oedema and infection scores was acceptable. Adhesion severity and oedema scores at 4 weeks were significantly lower with calcium alginate packing than with carboxymethyl cellulose. Infection severity scores also tended to be lower with calcium alginate than with carboxymethyl cellulose, but the difference was not significant. CONCLUSIONS: Calcium alginate nasal packing is associated with reduced severity of oedema and adhesions after endoscopic sinus surgery.

Anti-adhesive effect of a thermosensitive poloxamer applied after the removal of nasal packing in endoscopic sinus surgery: a randomised multicentre clinical trial.

OBJECTIVE: To compare the efficacies of a thermosensitive poloxamer (TPX) and Merogel in preventing adhesion applied after the removal of nasal packing in endoscopic sinus surgery as a non-inferiority trial. DESIGN: Randomised, multicentre, single-blind, active-controlled, matched-pair study. SETTING: Yonsei University Gangnam Severance Hospital, Korea University Guro Hospital. PARTICIPANTS: A total of 70 patients were enroled and underwent endoscopic sinus surgeries. Four of the patients did not complete their follow-up. Analysis of the 66 enroled patients having completed postoperative assessment was performed. The severity of rhinosinusitis was graded with a Lund-McKay CT score, and only those with bilateral disease and a CT score difference ≤2 between sinuses were included. MAIN OUTCOME MEASURES: An independent rhinologist from a third institution through a blinded assessment with digital photoendoscopy of the middle meati bilaterally taken postoperatively. RESULTS: In the blinded assessment, thermosensitive poloxamer (anti-adhesion rate: 92%) was similar to Merogel (anti-adhesion rate: 89%). Evaluation of the presence and grade of adhesion, oedema, and infection in the middle meatus revealed no significant differences between the thermosensitive poloxamer group and the Merogel group at all postoperative periods. CONCLUSION: Anti-adhesive effects of thermosensitive poloxamer are similar to those of Merogel. Therefore, thermosensitive poloxamer can be considered a safe alternative to Merogel for preventing adhesion in patients undergoing endoscopic sinus surgeries, and further evaluation of thermosensitive poloxamer as an anti-adhesive and primary packing material compared with the control using no packing is needed.

Fluoroscopy-aided thoracoscopic resection of pulmonary nodule localized with contrast media.

BACKGROUND: The pulmonary nodules have become the major indication of video-assisted thoracic surgery (VATS). Recently, several preoperative or intraoperative techniques for identifying small or deeply seated pulmonary nodules have facilitated thoracoscopic resection. We describe the new technique for detecting difficult lesions. METHODS: Preoperatively, we marked the visceral pleura near the pulmonary nodules with dye, simultaneously injected contrast media (1 water-soluble Optiray [Mallinckrodt Medical Inc, Quebec, Canada], 18 barium sulfate, 11 Lipiodol [Laboratoire Guerbet, Aulnay-sous-Bois, France]) into or around the nodule under computed tomography (CT) guidance. During VATS, we were able to easily and accurately detect and resect all the nodules localized with contrast media, of which the radiopacity was visualized on the portable fluoroscopic monitor. RESULTS: Between February 1996 and December 1998, we thoracoscopically resected 30 nodules in 28 patients (13 were women; age, 53 +/- 14 years). The resected nodules were 17 +/- 7.6 mm (range; 4 to 32 mm) in size, and 8.9 +/- 8 mm (range, 2 to 34 mm) in depth. The pathologic diagnosis of the nodules was benign in 20 and malignant in 10 (six primary cancers of lung and four metastatic cancers). There were only minor complications related CT localization. CONCLUSIONS: This new technique can help the surgeons detect and resect the difficult lesions with safety and rapidity by VATS without thoracotomy.

[A photoelastic study of the stress distributions in the surrounding tissues of the abutments of a fixed partial denture with secondary abutments].

The purpose of this study was to evaluate the stress distributions of fixed partial dentures with secondary abutments. In the case where the lower first premolar and the second premolar were missing, four 2-dimensional photoelastic models with the canine and the first molar as primary abutments with secondary abutments were prepared as follows; Model I: primary abutments only. Model II: primary abutments with the lateral incisor as the secondary abutment. Model III: primary abutments with the second molar as the secondary abutment. Model IV: primary abutments with the lateral incisor and the second molar as secondary abutments. Two-dimensional photoelastic stress analysis was used with the stress areas recorded photographically. A vertical load was applied to the pontic in each case. After the stress patterns in surrounding tissues of the abutments were observed and recorded, the conclusions were as follows: 1. In model I, applied force was distributed to the long axis of the abutments. 2. In model II, III, IV, all the secondary abutments showed compressive stresses. No tensile stresses were developed. 3. The mesial aspect of the lateral incisor and the distal aspect of the second molar as the secondary abutment showed no compressive stresses.

[A photoelastic study of the stress distribution in the surrounding tissues of the abutments of a fixed partial denture with tilted molar abutments].

The purpose of this study was to evaluate the stress distributions to the abutments of a fixed partial denture with tilted molar abutments. In cases of the lower 1st molar being missing four 2-dimensional photoelastic models with 3- unit fixed partial dentures of which the 2nd molars were tilted 0 degrees, 10 degrees, 20 degrees and 30 degrees toward the 2nd premolar were made. A vertical load of 50 lbs was applied to the 1st and 2nd molar in each case. Two-dimensional photoelastic stress analysis was used, and the stress areas were recorded photographically. The results were as follows; 1. When the vertical load was applied to pontic and 2nd molar on the central fossae, the magnitude of stress distribution of the surrounding tissues of the root of the 2nd premolar was increased incrementally with increasing inclination. 2. Under two loading conditions, the stress distributions were directed to the long axis of the abutments. 3. In this experiment, no stress distributions were observed on the mesial area of the mesial root of the second molar.