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Biosci Biotechnol Biochem ; 83(3): 551-560, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30526376

ABSTRACT

This study was undertaken to determine the effects of enzyme-treated Zizania latifolia (ETZL) and of its major compound tricin on skin photo-aging and to investigate the mechanisms involved. It was found ETZL and tricin suppressed matrix metalloproteinase (MMP) production and increased type I-procollagen production in UVB-irradiated human dermal fibroblasts (HDFs). Furthermore, ETZL and tricin significantly up-regulated the expressions of the antioxidant enzymes HO-1 and SOD1, reduced UVB-induced reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) induction by ROS and thereby attenuated activator protein-1 (AP-1) expression. In addition, ETZL and tricin both reduced the phosphorylations of IκBα and IKKα/ß and κB blocked the nuclear translocation of nuclear factor-κB (NF-κB) p65. These results show that ETZL have skin protective effects against UVB and suggest tricin as major efficacious material in ETZL protecting skin photoaging.


Subject(s)
Enzymes/metabolism , Fibroblasts/drug effects , Flavonoids/pharmacology , Poaceae/chemistry , Radiation-Protective Agents/pharmacology , Skin/cytology , Ultraviolet Rays/adverse effects , Fibroblasts/cytology , Fibroblasts/metabolism , Fibroblasts/radiation effects , Flavonoids/isolation & purification , Flavonoids/metabolism , Humans , Mitogen-Activated Protein Kinases/metabolism , NF-kappa B/metabolism , Radiation-Protective Agents/isolation & purification , Radiation-Protective Agents/metabolism , Reactive Oxygen Species/metabolism , Signal Transduction/drug effects , Signal Transduction/radiation effects , Skin Aging/drug effects , Skin Aging/radiation effects , Transcription Factor AP-1/metabolism
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