1.
Nuklearmedizin
; 22(3): 136-9, 1983 Jun.
Article
in English
| MEDLINE
| ID: mdl-6353374
ABSTRACT
Plasma clearance of 99mTc-N,N'-bis (1,2-mercaptoacetamido) ethylenediamine (DADS), 99mTc-DTPA and 131I-o-hippuran (OIH) was determined in rabbits from blood-concentration decay curves after single i.v. injection of the compounds. Dynamic scintigraphy was performed using the same three compounds, and "activity" curves were compared as observed over kidney ROIs. Both clearance values and renoscintigraphic curves were similar for 99mTc-DADS and 99mTc-DTPA but evidently different from those of OIH. Biliary excretion of 99mTc-DADS was also observed. It appears that, in contrast to other authors, 99mTc-DADS cannot serve as a substitute for 131I-o-hippuran.