ABSTRACT
The authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. Despite having been herself vaccinated in infancy she was not protected against the poliovirus. The clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia. The authors suggest serologic testing of patients born before 1967 especially if they are at risk of encountering the virus.
Subject(s)
Poliomyelitis/transmission , Poliovirus Vaccine, Oral/adverse effects , Adult , Feces/microbiology , Female , Humans , Infant , Male , Poliomyelitis/microbiology , Poliovirus/isolation & purificationABSTRACT
The treatment of the acute phase of stroke creates a difficult problem to the clinician. The presently used drugs lead to controversial results. The progress in knowledge of the pathogenesis of cerebral damage underlines the determinant role of the metabolic deficits in the ischemic areas. The effect on the clinical symptomatology of patients in the acute phase of stroke was studied during a double-blind comparative clinical trial with an alcaloid of Vinca minor (Pervincamine) which acts favorably against disturbances of oxydative glucose metabolism and of cerebral microcirculation. 20 patients divided into two homogeneous groups received during 5 days either Pervincamine (4 ampoules of 3 ml = 60 mg vincamine p.d.) + glycerol, or glycerol + placebo administered by i.v. infusion. Clinically the results indicate a greater improvement of the neurological status (objectivated by a neurological scale) with vincamine treatment than with placebo. Statistically the analysis confirms the highly significant effect of vincamine on motility of lower and upper limbs (p less than 0.02) and the significant effect on cranial nerves (homonymous hemianopsia and conjugated deviation of eyes) (p less than 0.05) and on the sphincter control level (p less than 0.05).
Subject(s)
Cerebrovascular Disorders/drug therapy , Glycerol/therapeutic use , Vinca Alkaloids/therapeutic use , Vincamine/therapeutic use , Adult , Aged , Cerebrovascular Disorders/physiopathology , Clinical Trials as Topic , Double-Blind Method , Electrocardiography , Female , Glycerol/adverse effects , Humans , Male , Middle Aged , Placebos , Time Factors , Vincamine/adverse effectsSubject(s)
Blindness/physiopathology , Cerebrovascular Circulation , Electroencephalography , Reading , Touch , Adult , Dominance, Cerebral , Female , Humans , Male , Middle Aged , Occipital Lobe/physiology , Parietal Lobe/physiology , Plethysmography, Impedance , Regional Blood Flow , Rest , Space Perception/physiology , Temporal Lobe/physiologySubject(s)
Brain/blood supply , Hemodynamics , Age Factors , Aged , Amino Acids/metabolism , Brain/metabolism , Brain/physiology , Humans , Lactates/metabolismABSTRACT
Cerebral impedance changes (F changes) indicating cerebral blood flow variations in the central and precentral areas were measured with a rheographic technique in normal subjects preparing for and carrying out a motor task. The time course of the F changes was studied and several significant correlations were established between the amount of F changes, their distribution and the motor performance. Our findings confirm that frontal and premotor regions play an important part in decision making.
