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J Appl Physiol (1985) ; 83(3): 681-7, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9292449

ABSTRACT

P-selectin is an adhesion receptor that has been shown to be important in the recruitment of eosinophils and lymphocytes in a variety of inflammatory conditions. Because cellular recruitment is thought to be a critical event in allergen-induced changes in airway responsiveness, we reasoned that P-selectin-deficient mice would exhibit reduced airway responsiveness and cellular trafficking noted in wild-type (+/+) mice. Both (+/+) and P-selectin-deficient (-/-) mice sensitized and challenged with ovalbumin (OVA/OVA) exhibited the same capacity to produce increased titers of total and OVA-specific immunoglobulin E. Airway responsiveness to methacholine was significantly greater in the (+/+) (OVA/OVA) animals than it was in the respective (-/-) (OVA/OVA) group or control groups (P = 0.0016). Bronchoalveolar lavage fluid from (-/-) (OVA/OVA) mice contained significantly fewer eosinophils and lymphocytes compared with the (+/+) (OVA/OVA) mice (P < 0.05). These results suggest that the predominant role of P-selectin in OVA-induced airway hyperresponsiveness is to promote the airway inflammatory response to allergen inhalation.


Subject(s)
P-Selectin/genetics , P-Selectin/metabolism , Respiratory Hypersensitivity/genetics , Respiratory Hypersensitivity/physiopathology , Airway Resistance/physiology , Animals , Antibody Formation/genetics , Antibody Formation/physiology , Bronchial Hyperreactivity/pathology , Bronchial Hyperreactivity/physiopathology , Bronchoalveolar Lavage Fluid/cytology , Cell Count , Cytokines/metabolism , Flow Cytometry , Immunoglobulin E/analysis , Immunoglobulin E/immunology , Immunoglobulin E/metabolism , Interleukin-4/metabolism , Lymphocyte Subsets/immunology , Mice , Mice, Inbred C57BL , Mice, Knockout , Ovalbumin/immunology , Respiratory Hypersensitivity/pathology , Respiratory System/metabolism , Respiratory System/pathology
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