ABSTRACT
Some studies have indicated that silent and perhaps pure mental forms of multiple sclerosis (MS) exist. With the aim of examining that, the records of 9478 autopsies from patients with mental disorders were reviewed. A total of 7252 had both clinical and histological diagnosis, and 7301 had only pathoanatomical diagnosis. Twenty-three patients were suspected of having MS, which were confirmed histologically in 14. None had unsuspected, silent or a pure mental form of MS. It is concluded that the risk of mistaking MS for a psychiatric disorder is small in MS high-risk area.
Subject(s)
Brain/pathology , Mental Disorders/pathology , Multiple Sclerosis/pathology , Diagnostic Errors , Humans , Multiple Sclerosis/diagnosis , Spinal Cord/pathologyABSTRACT
In 336 consecutive autopsies a total of 305 tumors were recorded in the large intestine. Of these, 184 were adenomas occurring in 26% of the 196 men and 17% of the 140 women, resulting in an overall prevalence of 22%, or 15% when standardized to the world standard population (WSP). The prevalence of adenomas increased with age, and a shift from distal to proximal location occurred in the older age groups, mostly accounted for by the greater tendency to multiplicity in old age. Regardless of age 57% of the cases of adenomas could have been identified by flexible sigmoidoscopy. The prevalence of hyperplastic polyps was 13%, and an association between these and adenomas was found. Five adenocarcinomas occurred in the study. With some exceptions, which are discussed in detail, the results are in accordance with studies from other countries with a high incidence of colorectal cancer and similar socioeconomic composition. The study supports the theory of the adenoma-carcinoma sequence.
Subject(s)
Adenoma/pathology , Colonic Neoplasms/pathology , Intestinal Polyps/pathology , Intestine, Large/pathology , Rectal Neoplasms/pathology , Adenoma/epidemiology , Adult , Aged , Autopsy , Colonic Neoplasms/epidemiology , Cross-Sectional Studies , Denmark , Female , Humans , Intestinal Polyps/epidemiology , Male , Middle Aged , Rectal Neoplasms/epidemiologyABSTRACT
A 76-year-old woman was admitted to the hospital in comatose condition. Her blood glucose was 1.7 mM. Immediately after intravenous glucose treatment she attained normal consciousness. The diagnosis of severe primary hypothyroidism was subsequently made and no sign of other diseases was detected. After thyroid replacement therapy fasting blood glucose levels rose to normal and no further hypoglycaemic episodes occurred. It is emphasized, that hypoglycaemia may be the direct cause of severely impaired consciousness in hypothyroidism requiring immediate and specific therapy.
