Outcome of revision arthroplasty for failed metal-on-metal total hip replacements; is there a relation with metal ions?

PURPOSE: We aimed to assess the early outcome following revision arthroplasty for failed metal-on-metal (MoM) total hip replacements (THR) due to adverse reaction to metal debris (ARMD). METHODS: We reviewed 106 consecutive revision arthroplasties. Case notes and radiological investigations were reviewed to assess the complications. Oxford Hip Score (OHS) and Euroqol (EQ-5D-3L) scores were used to assess the functional outcome and improvement of quality of life. RESULTS: At a mean follow-up of 20 months (12-48 months), the mean OHS was 28.7. Pain improved in 61% patients. A majority of patients were in level 2 for all the EQ-5D-3L dimensions. The overall complication rate was 16%. Survivorship free from further revision for any cause was 94.3% at 48 months. There was no correlation between pre-revision blood metal ions and the final outcome. CONCLUSIONS: Revision surgery for failed MoM hip replacement due to ARMD is associated with a relatively higher rate of complications and risk of chronic pain. There is poor correlation between serum metal ions and development of ARMD and outcome following revision surgery.

Adverse reaction to metal bearing leading to femoral stem fractures: a literature review and report of two cases.

Metal-on-metal (MoM) bearing in total hip replacement (THR) has a high failure rate due to adverse reaction to metal debris (ARMD). There is a spectrum of soft tissue and bony changes in ARMD including muscle necrosis and osteolysis. In our institution, more than 1500 MoM THRs were implanted since 2003. Recently, we have revised significant numbers of these. We report our experience and management of a mode of failure of MoM THR that has been infrequently reported-the distal femoral stem fracture. We report on two patients who presented with worsening pain attributable to fracture of the femoral stem. Severe femoral osteolysis led to loss of proximal stem support and eventual fatigue fracture of the component. Both patients were revised employing a posterior approach. Bone trephine was used to extract a well-fixed distal stem fragment without any windows. Both patients had successful outcome after revision with excellent pain relief and no complications.

Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements.

PURPOSE: Peri-prosthetic osteolysis is a major cause for revision hip arthroplasty; various cytokines including those in the osteoclastogenesis pathway have been identified as potentially key in the osteolysis process. Adverse reactions to metal debris in metal-on-metal total hip replacements have led to an increase in revision procedures. This study examines the levels of osteoclastogenesis-related cytokines in serum and synovial fluid samples obtained from patients at the time of revision metal-on-metal total hip replacement and compares between patients with and without radiographic evidence of peri-prosthetic osteolysis. METHODS: Sandwich ELISA techniques were used to detect IL-6, IL-18, M-CSF, sRANKL and OPG in the samples. Results were analysed with linear regression, Fisher's tests and t-tests; p<0.05 considered significant. Samples from 36 patients (18 with osteolysis, 18 without osteolysis) were analysed. RESULTS: There was wide variation in the detectable levels of cytokines. No significant differences were found between patients with and without osteolysis in mean synovial fluid levels of IL-6 (p = 0.863), IL-18 (p = 0.324), M-CSF (p = 0.508), sRANKL (p = 0.884), OPG (p = 0.776) or mean serum levels of OPG (p = 0.993) or sRANKL (p = 0.565) (insufficient detection of IL-6, IL-18 or M-CSF in serum samples). A correlation was found between synovial fluid levels of IL-6 and OPG in patients without osteolysis (r2 = 0.618, p<0.001) but not with osteolysis (r2 = 0.0004). CONCLUSIONS: These results indicate that the process of peri-prosthetic osteolysis is complex and multifactorial; there may also be an influence of metallosis. Further research is needed to increase understanding of peri-prosthetic osteolysis and influence clinical practice.

The Interchangeability of Plasma and Whole Blood Metal Ion Measurement in the Monitoring of Metal on Metal Hips.

One hundred and twenty six paired samples of plasma and whole blood were measured with inductively coupled plasma mass spectrometry technique for metal ions analysis to determine a relationship between them. There was a significant difference between the mean plasma and whole blood concentrations of both cobalt (Co) and chromium (Cr) (p < 0.0001 for both Co and Cr). The mean ratio between plasma and whole blood Cr and Co was 1.56 (range: 0.39-3.85) and 1.54 (range: 0.64-18.26), respectively, but Bland and Altman analysis illustrated that this relationship was not universal throughout the range of concentrations. There was higher variability at high concentrations for both ions. We conclude that both these concentrations should not be used interchangeably and conversion factors are unreliable due to concentration dependent variability.

High failure rate of the R3 metal-on-metal total hip arthroplasty.

We report our failures with the use of the R3 metal-on-metal bearing. Forty six patients had an R3 acetabular system metal-on-metal THR in our centre between March 2007 and March 2009. All operations were performed using femoral components and appropriately matched femoral heads manufactured by Smith and Nephew. Twelve patients underwent revision surgery for adverse reaction to metal debris (ARMD). The median acetabular inclination was 40 degrees (range 21.1-49.1) and the median acetabular anteversion was 7.5 degrees (range 3.3-10.4). The median serum Cobalt was 9.9 µg/L (range 3.1-45) and the median serum Chromium was 5.8 µg/L (range 1.8-19.3). The time to revision was 39.2 months (range 13-53). Our current failure rate is 24%.

The Correlation of Serum Metal Ions with Functional Outcome Scores at Three-to-Six Years following Large Head Metal-on-Metal Hip Arthroplasty.

Based on success of hip resurfacing, large head Metal on Metal (MoM) hip arthroplasty has gained significant popularity in recent years. There are growing concerns about metal ions related soft tissue abnormalities. The aim of this study was to define a correlation of metal ions with various functional outcome scores following large head MoM hip arthroplasty. Consecutive cohort of 70 patients (76 hips) with large head MoM hip arthroplasty using SL-Plus femoral stem and Cormet acetabular component were prospectively followed up. An independent observer assessed the patients which included serology for metal ion levels and collection of Oxford Hip, Harris hip, WOMAC, SF-36 & modified UCLA scores. Median serum cobalt and chromium levels were 3.10 µg/L (0.35-62.92) and 4.21 µg/L (0.73-69.27) with total of median 7.30 µg/L (2.38-132.19). The median Oxford, Harris, WOMAC, SF-36 and modified UCLA scores were 36 (6-48), 87 (21-100), 36 (24-110), 104 (10-125), and 3 (1-9), respectively. Seventeen patients had elevated serum cobalt and chromium levels ≥7 µg/L. There was no significant correlation between serum metal ion levels with any of these outcome scores. We recommend extreme caution during follow up of these patients with large head MoM arthroplasty.

Pull-out strength of a polished tapered stem is improved by placing bone cement over the shoulder of the implant.

Displacement of a polished stem while attempting closed reduction of a dislocated total hip or during dislocation itself is a rare but significant complication. Our aim was to assess whether applying bone cement over the shoulder of the implant can help to prevent this. We conducted an in vitro mechanical study with tensile testing machine. We cemented 7 sawbones with a standard cementing technique and another 7 with additional cement over the shoulder of the implant. The mean pull-out force in the routine cementing technique was 2066 N (SD, 256.65), and it was 3220 N (SD, 312.22) for the group with the cement on the shoulder. There is a statistically significant difference of 1154 N. We recommend that when a polished stem is used, bone cement should be applied over the shoulder of the implant.