ABSTRACT
In an open, randomized, multicenter, controlled clinical trial in the US, 773 adults were administered either a combination hepatitis vaccine (Twinrix: 720 EL.U inactivated hepatitis A antigen and 20 mcg recombinant hepatitis B surface antigen per milliliter) on a 0, 1, 6 month schedule or corresponding monovalent vaccines concurrently (Havrix, 1440 EL.U/ml of hepatitis A antigen at 0, 6 months and Engerix-B, 20 mcg of hepatitis B surface antigen at 0, 1, 6 months). Non-inferiority testing for the primary endpoint, severe soreness, and equivalence testing for the secondary endpoints, anti-HAV seroconversion and anti-HBs seroprotection, showed that safety and immunogenicity were comparable in the two groups.
Subject(s)
Hepatitis A Vaccines/immunology , Hepatitis B Vaccines/immunology , Vaccines, Synthetic/immunology , Adult , Erythema/etiology , Female , Gastrointestinal Diseases/etiology , Headache/etiology , Hepatitis A Antibodies , Hepatitis A Vaccines/adverse effects , Hepatitis Antibodies/biosynthesis , Hepatitis Antibodies/immunology , Hepatitis B Antibodies/biosynthesis , Hepatitis B Antibodies/immunology , Hepatitis B Surface Antigens/immunology , Hepatitis B Vaccines/adverse effects , Humans , Immunization Schedule , Male , Pain/etiology , Prospective Studies , Safety , United States , Vaccination , Vaccines, Combined , Vaccines, Synthetic/adverse effectsABSTRACT
Maryland has the second highest statewide cancer mortality rate in the nation. This ranking is primarily due to high death rates for the most prevalent cancers: lung, breast, colon, and prostate. Based on the recent literature and the October 1991 preventive medicine grand rounds at the Johns Hopkins University School of Hygiene and Public Health, this paper summarizes several current viewpoints on cancer mortality in Maryland and the progress that has been made by recently instituted state and community initiatives.
Subject(s)
Neoplasms/mortality , Female , Humans , Male , Maryland/epidemiology , Neoplasms/prevention & control , Preventive Health Services , Risk FactorsABSTRACT
Dendriform pulmonary ossification (DPO) is a rare condition characterized by branching bony spicules found in association with pulmonary fibrosis. The authors report two cases, the first of which occurred in a patient with acute myeloblastic leukemia and was associated with the unique finding of leukemic involvement of marrow spaces in the metaplastic bone. The second case showed DPO in combination with asbestosis, a heretofore unreported association.
