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Solution conformation of d(C(4)ACAC(4)TGT)(2); an intramolecularly folded i-motif from the insulin minisatellite.
Jolad, Vandana V; Murad, Fatima K; Arnold, John R P; Fisher, Julie.
Org Biomol Chem ; 3(12): 2234-6, 2005 Jun 21.
Article in English | MEDLINE | ID: mdl-16010354

ABSTRACT

A 28-mer sequence taken from the insulin minisatellite is shown, through NMR and UV thermal melting studies, to form an intramolecular i-motif with two ACA and one TGT loop that persists to near neutral pH and room temperature.


Subject(s)
Insulin/chemistry , Minisatellite Repeats/genetics , Insulin/genetics , Nuclear Magnetic Resonance, Biomolecular , Spectrophotometry, Ultraviolet
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