Spin injection enhancement in CW VECSEL at room temperature using push-pull optical pumping.

We report the enhancement of spin injection efficiency in an external-cavity VCSEL based on a non-resonant pumping coupled with a polarized optical resonant illumination. This double pumping scheme allows both the injection of spin polarized electrons in the conduction band and the selection of the spin orientation for the electron/hole recombination laser process. Experimentally, a flip of the polarization state of the laser is achieved with an ellipticity of +31° (spin down) and -33° (spin up), so an increase of about 50% of the ellipticity is achieved in comparison to an optical non-resonant pumping alone.

VSPIN: a new model relying on the vectorial description of the laser field for predicting the polarization dynamics of spin-injected V(e)CSELs.

A new vectorial model (VSPIN) based on the Jones formalism is proposed to describe the polarization dynamics of spin injected V(e)CSELs. This general modelling framework accounts for spin injection effects as a gain circular dichroism in the active medium and provides guidelines for developing functional spin-controlled lasers. We investigate the detrimental role of phase anisotropy on polarization switching and show that it can be overcome by preparing the laser cavity to achieve efficient polarization switching under low effective spin injection. The VSPIN model predictions have been confirmed experimentally and explain the polarization behavior of spin-VCSELs reported in the literature.

Binding Specificity of Native Odorant-Binding Protein Isoforms Is Driven by Phosphorylation and O-N-Acetylglucosaminylation in the Pig Sus scrofa.

Odorant-binding proteins (OBP) are secreted in the nasal mucus at the vicinity of olfactory receptors (ORs). They act, at least, as an interface between hydrophobic and volatile odorant molecules and the hydrophilic medium bathing the ORs. They have also been hypothesized to be part of the molecular coding of odors and pheromones, by forming specific complexes with odorant molecules that could ultimately stimulate ORs to trigger the olfactory transduction cascade. In a previous study, we have evidenced that pig olfactory secretome was composed of numerous olfactory binding protein isoforms, generated by O-GlcNAcylation and phosphorylation. In addition, we have shown that recombinant OBP (stricto sensu) produced in yeast is made up of a mixture of isoforms that differ in their phosphorylation pattern, which in turn determines binding specificity. Taking advantage of the high amount of OBP secreted by a single animal, we performed a similar study, under exactly the same experimental conditions, on native isoforms isolated from pig, Sus scrofa, nasal tissue. Four fractions were obtained by using strong anion exchange HPLC. Mapping of phosphorylation and O-GlcNAcylation sites by CID-nanoLC-MS/MS allowed unambiguous localization of phosphosites at S13 and T122 and HexNAc sites at S13 and S19. T112 or T115 could also be phosphorylated. BEMAD analysis suggested extra phosphosites located at S23, S24, S41, S49, S57, S67, and T71. Due to the very low stoichiometry of GlcNAc-peptides and phosphopeptides, these sites were identified on total mixture of OBP isoforms instead of HPLC-purified OBP isoforms. Nevertheless, binding properties of native OBP isoforms to specific ligands in S. scrofa were monitored by fluorescence spectroscopy. Recombinant phosphorylated OBP-Pichia isoforms bind steroids and fatty acids with slight differences. Native isoforms, that are phosphorylated but also O-GlcNAcylated show radically different binding affinities for the same compounds, which strongly suggests that O-GlcNAcylation increases the binding specificity of OBP isoforms. These findings extend the role of O-GlcNAc in regulating the function of proteins involved in many mechanisms of metabolic homeostasis, including extracellular signaling in olfaction. Data is available via ProteomeXChange with identifier PXD011371.

Compensation of the residual linear anisotropy of phase in a vertical-external-cavity-surface-emitting laser for spin injection.

We report on the compensation of the linear anisotropy of phase in a vertical-external-cavity surface-emitting laser from 21 to 0.5 mrad with an intracavity PLZT electro-optical ceramic. It allows dynamic and accurate control of the laser linear anisotropy, as well as dynamic control of the laser polarization eigenstates. At the birefringence compensation point, we observe an elliptical polarization state with 41° of ellipticity, rotated from its initial position of 32°. The experimental observations are in close agreement with the theoretical predictions. Finally, we are able to demonstrate control of the polarization state with spin injection.

Multi-kW peak power acousto-optically tunable thulium-doped fiber laser system.

We demonstrate a core-pumped Q-switched thulium-doped fiber laser system with fast tunability capability over 100 nm without any movable part. With up to 7 kW peak power in a diffraction-limited beam, this source is well adapted for pumping a frequency agile mid-IR parametric oscillator or amplifier based on Quasi-Phase-Match single-period crystals.