ABSTRACT
OBJECTIVE: The present study has focused on the identification of differences between the expression pattern of TGF-ß signaling pathway genes in athletes after exercise. MATERIALS AND METHODS: The study group consisted of three healthy cyclists, which were collected pre-exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF-ß signal transduction pathway was performed in peripheral blood mononuclear cells using HG-U133A oligonucleotide microarrays. RESULTS: A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2. CONCLUSIONS: The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF-ß signaling can be involved in the process of adaptation of human organism to physical exertion.
