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1.
Nutrients ; 14(9)2022 Apr 28.
Article in English | MEDLINE | ID: mdl-35565804

ABSTRACT

Zhou and colleagues are commended for their innovative research on the tolerability of "low-viscosity" fibre supplements in symptomatic diabetic gastroparesis patients [...].


Subject(s)
Gastroparesis , Dietary Fiber , Humans , Nutrients , Pilot Projects , Viscosity
2.
Cureus ; 13(9): e18062, 2021 Sep.
Article in English | MEDLINE | ID: mdl-34552840

ABSTRACT

We report a seven-year follow-up of a 43-year-old Hispanic female with severe diabetic gastroparesis (GP) and a 42.5 kg weight loss (45% of body mass), who required feeding jejunostomy tube placement. The patient had an excellent response to a treatment regime directed at increasing stool bulk, enhancing gut transit, and mobilizing intestinal gas by using dietary fiber supplements and osmotic laxatives with as needed tap water enemas. Hospital cost savings for this patient exceeded $125,000 annually. This case study suggests that constipation may substantially contribute to GP.

3.
J Invest Dermatol ; 127(11): 2563-76, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17554370

ABSTRACT

Single base substitution mutations in codons 248 and 273 of TP53 and codon 12 Kirsten-ras (KRAS) are commonly found in human carcinomas. To determine whether these mutations also occur in normal and inflamed tissues from which carcinomas arise, we utilized the ultra-sensitive polymerase chain reaction/restriction endonuclease/ligase chain reaction mutation assay. Ninety samples of genital skin, including lichen sclerosus (LS) affected skin, adjacent normal and non-adjacent normal, were assayed. Mutations were detected in 103 of 349 assays and consisted of KRAS G34A, G34T, G35A, and TP53 C742T, G818C, C817T, and G818A mutations. Mutant prevalence varied from 1 to 20 per 10(6) wild-type cells. Mutations occurred significantly more frequently in LS (78/224 (35%)) than adjacent normal (20/88 (23%)) and non-adjacent normal genital skin (5/38 (13%)). KRAS G34A mutation was relatively common to all classes of specimen, whereas TP53 gene C742T and G818C mutations were significantly more frequent in LS than normal genital skin. In matched samples, immunohistochemistry evaluation of p53 protein expression revealed the presence of epidermal p53 clones in LS whose presence and number significantly correlated with the presence of TP53 C742T and G818C mutations. Based on these results, it appears oncogenic point mutations occur in normal genital skin, and are selected for in LS.


Subject(s)
Genomic Instability/genetics , Point Mutation/genetics , Vulvar Lichen Sclerosus/genetics , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/genetics , Carcinoma, Squamous Cell/metabolism , Cell Line, Tumor , Disease Progression , Female , Humans , Middle Aged , Oxidative Stress/genetics , Proto-Oncogene Proteins/genetics , Proto-Oncogene Proteins/metabolism , Proto-Oncogene Proteins p21(ras) , Tumor Suppressor Protein p53/genetics , Tumor Suppressor Protein p53/metabolism , Vulvar Neoplasms/genetics , Vulvar Neoplasms/metabolism , ras Proteins/genetics , ras Proteins/metabolism
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