ABSTRACT
A new ent-atisane diterpenoid, ent-3α-acetoxy-1ß,16ß,17-trihydroxyatisane (1), along with four known compounds, 3,3',4'-tri-O-methylellagic acid (2), (R)-(+)-lasiodiplodin (3), taraxerol (4) and syringic acid (5) were isolated from the aerial parts of Euphorbia antiquorum L. The structure of compound 1 was identified by interpretation of their spectroscopic data and comparison with those reported in the literature.
Subject(s)
Diterpenes/chemistry , Euphorbia/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure , Oleanolic Acid/analogs & derivatives , Oleanolic Acid/chemistry , Plant Components, Aerial/chemistryABSTRACT
In the original publication of the article, figure 1 was published incorrectly. The correct version of figure 1 is provided below.
ABSTRACT
Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xanthones. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and Hep G2 cell lines). Compounds 2, 5, and 7 showed significant cytotoxic effects against all cell lines with IC50 values in the range of 0.91-9.93 µM, while 10 exhibited cytotoxicity against the KB, HeLa S-3, and HT-29 cells with IC50 values of 7.39, 6.07, and 8.11 µM, respectively. Compound 12 exhibited cytotoxicity against both KB and HeLa S-3 cells with IC50 values of 7.28 and 9.84 µM.
ABSTRACT
Chemical investigation of the CH2Cl2 and MeOH crude extracts of the roots of Melodorum fruticosum Lour. led to the isolation of 15 known compounds, of which 5, 10, and 12-15 are reported for the first time from this plant. In addition, melodorinol (7) was derivatized to afford six new (7a-7d and 7f-7g) analogues and one known compound (7e). Their structures were identified on the basic of spectroscopic data Most of them were evaluated for their cytotoxicity against KB, HeLa, MCF-7 and HepG-2 cell lines. Compounds 4 and 7b were the most potent to all cell lines.
Subject(s)
Alkenes/chemistry , Annonaceae/chemistry , Plant Roots/chemistry , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Cell Line, Tumor , Humans , Molecular StructureABSTRACT
Feronielloside (1), a new furanocoumarin glycoside, was isolated from roots of Feroniella lucida. The structure of 1 was elucidated by combined spectroscopic and chemical analysis. The absolute configuration of the chiral center in geranyl-derived side chain was confirmed by modified Mosher's method. Feronielloside inhibited acetylcholinesterase with IC(50) value of 24.7 mM.
