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1.
Transl Psychiatry ; 9(1): 258, 2019 10 17.
Article in English | MEDLINE | ID: mdl-31624239

ABSTRACT

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5-BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10-21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.


Subject(s)
Attention Deficit Disorder with Hyperactivity/genetics , Autism Spectrum Disorder/genetics , DNA Copy Number Variations , Schizophrenia/genetics , Adolescent , Adult , Case-Control Studies , Female , Genetic Predisposition to Disease , Genome-Wide Association Study , Humans , Iceland , Male , Norway , Polymorphism, Single Nucleotide
2.
Nature ; 505(7483): 361-6, 2014 Jan 16.
Article in English | MEDLINE | ID: mdl-24352232

ABSTRACT

In a small fraction of patients with schizophrenia or autism, alleles of copy-number variants (CNVs) in their genomes are probably the strongest factors contributing to the pathogenesis of the disease. These CNVs may provide an entry point for investigations into the mechanisms of brain function and dysfunction alike. They are not fully penetrant and offer an opportunity to study their effects separate from that of manifest disease. Here we show in an Icelandic sample that a few of the CNVs clearly alter fecundity (measured as the number of children by age 45). Furthermore, we use various tests of cognitive function to demonstrate that control subjects carrying the CNVs perform at a level that is between that of schizophrenia patients and population controls. The CNVs do not all affect the same cognitive domains, hence the cognitive deficits that drive or accompany the pathogenesis vary from one CNV to another. Controls carrying the chromosome 15q11.2 deletion between breakpoints 1 and 2 (15q11.2(BP1-BP2) deletion) have a history of dyslexia and dyscalculia, even after adjusting for IQ in the analysis, and the CNV only confers modest effects on other cognitive traits. The 15q11.2(BP1-BP2) deletion affects brain structure in a pattern consistent with both that observed during first-episode psychosis in schizophrenia and that of structural correlates in dyslexia.


Subject(s)
Autistic Disorder/genetics , Cognition/physiology , DNA Copy Number Variations/genetics , Genetic Predisposition to Disease , Schizophrenia/genetics , Adolescent , Adult , Aged , Brain/abnormalities , Brain/anatomy & histology , Brain/metabolism , Case-Control Studies , Chromosome Deletion , Chromosomes, Human/genetics , Chromosomes, Human, Pair 15/genetics , Dyslexia/genetics , Female , Fertility/genetics , Heterozygote , Humans , Iceland , Learning Disabilities/genetics , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Phenotype , Young Adult
3.
PLoS One ; 6(8): e23371, 2011.
Article in English | MEDLINE | ID: mdl-21853121

ABSTRACT

Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (GWAS) of knee OA in Japanese populations. The frequencies for rs10947262 were compared in 36,408 controls and 5,749 knee OA cases from European-descent populations. rs7775228 was tested in 32,823 controls and 1,837 knee OA cases of European descent. The risk (major) allele at rs10947262 in Caucasian samples was not significantly associated with an odds ratio (OR)  = 1.07 (95%CI 0.94 -1.21; p = 0.28). For rs7775228 the meta-analysis resulted in OR = 0.94 (95%CI 0.81-1.09; p = 0.42) for the allele associated with risk in the Japanese GWAS. In Japanese individuals these two SNPs are in strong linkage disequilibrium (LD) (r(2) = 0.86) with the HLA class II haplotype DRB1*1502 DQA1*0103 DQB1*0601 (frequency 8%). In Caucasian and Chinese samples, using imputed data, these SNPs appear not to be in LD with that haplotype (r(2)<0.07). The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals.


Subject(s)
Genetic Predisposition to Disease , Genome-Wide Association Study , HLA-D Antigens/genetics , Membrane Glycoproteins/genetics , Osteoarthritis, Knee/genetics , Polymorphism, Single Nucleotide/genetics , White People/genetics , Aged , Butyrophilins , Case-Control Studies , Female , Genetic Loci/genetics , Genetic Markers , Genetics, Population , Humans , Linkage Disequilibrium/genetics , Male , Meta-Analysis as Topic , Middle Aged , Reproducibility of Results
4.
Ann Hum Genet ; 74(3): 233-47, 2010 May.
Article in English | MEDLINE | ID: mdl-20529015

ABSTRACT

We propose two methods to evaluate the statistical significance of differences in linkage disequilibrium (LD) between populations, where LD is measured by the standardised parameter D'. The first method is based on bootstrapping individuals within populations in order to test LD differences for each pair of loci. Using this approach we propose a solution to the problem of testing multiple locus-pairs by means of a single test for the number of pairs that exhibit significant LD differences among populations. The second method provides the Bayesian posterior probability that one population has greater LD than the other for each locus pair. Both methods can handle genotypes with unknown phase, and are demonstrated using two data sets. For the purpose of demonstration, we apply the methods to two different sets of data from humans. First, we explore the issue of LD differences between reproductively isolated populations using a new data set of twelve Xq25 microsatellites, typed in four European populations. Second, we examine evidence for LD differences between Alzheimer cases and controls from the Icelandic population using 19 single nucleotide polymorphisms (SNPs) from a 97 kb region flanking the Apolipoprotein E (APOE) gene on chromosome 19.


Subject(s)
Genetics, Population , Linkage Disequilibrium , Alzheimer Disease/genetics , Chromosomes, Human, X , Genetic Predisposition to Disease , Humans , Iceland , Microsatellite Repeats , Polymorphism, Single Nucleotide , White People/genetics
5.
Nat Genet ; 40(11): 1313-8, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18849993

ABSTRACT

To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide SNP association study of 930 Icelanders with BCC and 33,117 controls. After analyzing 304,083 SNPs, we observed signals from loci at 1p36 and 1q42, and replicated these associations in additional sample sets from Iceland and Eastern Europe. Overall, the most significant signals were from rs7538876 on 1p36 (OR = 1.28, P = 4.4 x 10(-12)) and rs801114 on 1q42 (OR = 1.28, P = 5.9 x 10(-12)). The 1p36 locus contains the candidate genes PADI4, PADI6, RCC2 and ARHGEF10L, and the gene nearest to the 1q42 locus is the ras-homolog RHOU. Neither locus was associated with fair pigmentation traits that are known risk factors for BCC, and no risk was observed for melanoma. Approximately 1.6% of individuals of European ancestry are homozygous for both variants, and their estimated risk of BCC is 2.68 times that of noncarriers.


Subject(s)
Carcinoma, Basal Cell/genetics , Chromosomes, Human, Pair 1/genetics , Genetic Predisposition to Disease , Melanoma/genetics , Mutation/genetics , Pigmentation/genetics , Skin Neoplasms/genetics , Adipose Tissue/metabolism , Adolescent , Adult , Aged , Aged, 80 and over , Aging , Alleles , Carcinoma, Basal Cell/diagnosis , Carcinoma, Squamous Cell/genetics , Chromosomal Proteins, Non-Histone/genetics , Chromosomal Proteins, Non-Histone/metabolism , Guanine Nucleotide Exchange Factors/genetics , Guanine Nucleotide Exchange Factors/metabolism , Humans , Middle Aged , Models, Genetic , Polymorphism, Single Nucleotide/genetics , Quantitative Trait, Heritable , RNA/metabolism , Skin Neoplasms/diagnosis
6.
Nat Genet ; 40(6): 703-6, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18438407

ABSTRACT

We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.


Subject(s)
Breast Neoplasms/genetics , Chromosomes, Human, Pair 5/genetics , Genetic Predisposition to Disease , Genetic Variation , Receptors, Estrogen/metabolism , Adenocarcinoma/genetics , Adenocarcinoma/metabolism , Adenocarcinoma/pathology , Adult , Aged , Aged, 80 and over , Apoptosis , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/genetics , Carcinoma, Ductal, Breast/metabolism , Carcinoma, Ductal, Breast/pathology , Carcinoma, Intraductal, Noninfiltrating/genetics , Carcinoma, Intraductal, Noninfiltrating/metabolism , Carcinoma, Intraductal, Noninfiltrating/pathology , Carcinoma, Lobular/genetics , Carcinoma, Lobular/metabolism , Carcinoma, Lobular/pathology , Carcinoma, Medullary/genetics , Carcinoma, Medullary/metabolism , Carcinoma, Medullary/pathology , Case-Control Studies , Cohort Studies , Female , Humans , International Agencies , Male , Middle Aged , Polymorphism, Single Nucleotide , Prognosis , Receptor, Fibroblast Growth Factor, Type 2/genetics , Receptor, Fibroblast Growth Factor, Type 2/metabolism , Ribosomal Proteins/genetics , Ribosomal Proteins/metabolism
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