1.
Bioorg Med Chem Lett
; 17(21): 5740-3, 2007 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-17869104
ABSTRACT
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
