[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease]. / Cutis laxa adquirido asociado a gammapatía monoclonal y enfermedad por depósito de cadenas ligeras lambda.

Cutis laxa is a rare entity characterized clinically by redundant skin that gives an appearance of premature aging. The appearance relates to a loss of elasticity because of the destruction of elastic fibers that affects the skin and other organs. It may be associated with inflammatory conditions or diseases, such as plasma cell dyscrasias. We report the case of a 54-year-old man with acquired cutis laxa, which preceded the development of IgG-lambda monoclonal gammopathy with lambda light chain deposits in the kidney. The patient had a fatal outcome owing to severe and rapidly progressive renal failure. We emphasize the importance of recognizing a plasma cell dyscrasia in a patient with cutis laxa, although this association is rare.

Pityriasis lichenoides chronica associated with herpes simplex virus type 2.

Introduction. Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. Case Report. A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. Positive serologies to herpes simplex virus type 2 were detected. Histopathological examination of one of the lesions was consistent with a diagnosis of pityriasis lichenoides chronica. Discussion. Pityriasis lichenoides is a rare cutaneous entity of an unknown cause which includes different clinical presentations. A number of infectious agents have been implicated based on the clustering of multiple outbreaks and elevated serum titers to specific pathogens (human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, Toxoplasma gondii, and herpes simplex virus). In our patient, resolution of cutaneous lesions coincided with the administration of antiviral drugs and clinical improvement in each genital herpes recurrence. In conclusion, we report a case in which cutaneous lesions of pityriasis lichenoides chronica and a herpes simplex virus-type 2-mediated disease have evolved concomitantly.

Follicular acneiform eruption induced by bevacizumab.

Bevacizumab is a recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). This antibody, in combination with other antineoplastic agents, is currently used to treat various neoplasms, including colorectal, lung, breast, kidney cancer, and glioblastoma. It is also being used as an off-label intravitreal agent in the treatment of proliferative (neovascular) eye diseases. We report the development of a skin rash with two different patterns in a patient with a hemangiopericytoma of the meninges, a rare aggressive sarcoma, who was treated with repeated intravenous injections of bevacizumab.

Disseminated fusariosis in immunocompromised patients.

Immunocompromised patients are at high risk of developing serious disseminated infections by opportunistic fungi (Aspergillus, Candida, and Fusarium spp), which frequently present as cutaneous lesions, sometimes as a first sign. Prolonged and deep neutropenia, immunodepressive treatments (systemic steroids and chemotherapy) and severe T-cell immunodeficiency are the most important risk factors. We report 2 patients with acute lymphoblastic leukemia, who developed multiple tender erythematous skin lesions on their legs and arms during chemotherapy treatment. Skin biopsies for histology and culture studies established the diagnosis of Fusarium infection. They received treatment with systemic antifungal and granulocyte colony-stimulting factor. The infection responded after recovering from neutropenia. Early diagnosis and treatment is very important to improve the prognosis, because these infections in immunodepressed hosts have a high mortality rate.

Onicomicosis por Scedosporium apiospermum con buena respuesta a terbinafina / Onichomycose by scedosporium apiospermum. Good response to terbinafine

En los últimos años, estamos asistiendo a un aumento de patógenos fúngicos; sobre todo en pacientes inmunodeprimidos, que hasta hace poco eraninfrecuentes. Entre los nuevos patógenos se encuentra el Scedosporium apiospermum. Estos hongos plantean el problema de su resistencia a los antifúngicosy de la poca correlación que existe entre las sensibilidades in vitro e in vivo. Describimos el caso de un varón inmunocompetente, con una onicomicosispor dicho hongo y buena respuesta a Terbinafina

In the last years, we have observed an increase of pathogenic fungi, overcoat in inmunocompromised patients, that until now were quite unusual.Scedosporium apiospermum is one of those new pathogens. Those yeast present resistance to antifungal agents and poor relation between sensibili-zation in vitro and in vivo. An inmunocompetent man with onichomycosis by s. apiospermum with good respons to terbinafine is reported

Displasia ectodérmica hidrótica (síndrome de Clouston) / Hydrotic ectodermal dysplasia (Clouston's syndrome)

Se comunica un caso de Displasia Ectodérmica Hidrótica en un varón de 24 años, que inició sintomatología a los 3 meses de edad. Presenata alteraciones de las uñas y del cabello, hiperqueratosis palmoplantar y áreas de poiquilodermia en muslos. La sudoración es normal. El patrón dermatoglífico muestra gran desestructuración de las crestas epidérmicas

Displasia ectodérmica hidrótica (síndrome de Clouston) / Hydrotic ectodermal dysplasia (Cloustons syndrome)

Se comunica un caso de Displasia Ectodérmica Hidrótica en un varón de 24 años, que inició sintomatología a los 3 meses de edad. Presenata alteraciones de las uñas y del cabello, hiperqueratosis palmoplantar y áreas de poiquilodermia en muslos. La sudoración es normal. El patrón dermatoglífico muestra gran desestructuración de las crestas epidérmicas (AU)