Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066).

INTRODUCTION: There was a growing need for practical guidelines for the most common OIs in Germany and Austria under consideration of the local epidemiological conditions. MATERIALS AND METHODS: The German and Austrian AIDS societies developed these guidelines between March 2010 and November 2011. A structured Medline research was performed for 12 diseases, namely Immune reconstitution inflammatory syndrome, Pneumocystis jiroveci pneumonia, cerebral toxoplasmosis, cytomegalovirus manifestations, candidiasis, herpes simplex virus infections, varizella zoster virus infections, progressive multifocal leucencephalopathy, cryptosporidiosis, cryptococcosis, nontuberculosis mycobacteria infections and tuberculosis. Due to the lack of evidence by randomized controlled trials, part of the guidelines reflects expert opinions. The German version was accepted by the German and Austrian AIDS Societies and was previously published by the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF; German Association of the Scientific Medical Societies). CONCLUSION: The review presented here is a translation of a short version of the German-Austrian Guidelines of opportunistic infections in HIV patients. These guidelines are well-accepted in a clinical setting in both Germany and Austria. They lead to a similar treatment of a heterogeneous group of patients in these countries.

[GambiaDentCare - evaluation of a primary oral health-care programme in West Africa]. / GambiaDentCare - Evaluierung eines zahnmedizinischen Grundversorgungsprogramms in Westafrika.

STUDY AIM: Atraumatic restorative treatment, developed in the mid 1980s, was a milestone in primary oral health care in developing countries. In 2001, the basic package of oral care was implemented in Gambia (West Africa) by training nurses to become community oral health workers. It was therefore the aim of this study to evaluate the processes of the operative units of this programme. METHODS: The study was conducted in the form of a visitation, an employee attitude survey, and an analysis of the medical records. RESULTS: The evaluation revealed a continuous oral health care by competent community oral health workers in 5 out of 8 units. The patient catchment area considerably exceeded the village limits. Predominantly, pain therapy as a result of dental caries was administered with a restoration-extraction ratio of 1:10. Within a 12-month period, 5,524 patients of all ages were treated. The dental supply rate was 35%. CONCLUSIONS: Health care delivery in a primary oral health-care programme in the Repubilc of Gambia with community oral health workers was rated successfully. There is room for improvement in the organisational supervision of the operative units. The curriculum of future trainings should be adapted to changing epidemiological trends.

Inter-annual plasticity of squid life history and population structure: ecological and management implications.

Population size and structure, as well as individual growth rates, condition, and reproductive output, respond to environmental factors, particularly in short-lived and fast-growing squid species. We need to understand the mechanisms through which populations respond to environmental conditions, to predict when or if established relationships, used as management tools to forecast recruitment strength, might break down completely. Identifying characteristics of successful recruits who have grown under different environmental scenarios may improve our understanding of the mechanistic connections between environmental conditions and the temporal variation in life history characteristics that ultimately affect recruitment. This 5-year study sought to determine the association between key life history characteristics of southern calamary Sepioteuthis australis (growth rate, body size, and patterns of repro-somatic energy allocation) and the environmental conditions experienced by individuals on the east coast of Tasmania, Australia. Among years, all population and individual parameters examined were highly variable, despite the environmental regime during the study not encompassing the extremes that may occur in this dynamic region. Temperature was not clearly associated with any of the individual or population differences observed. Populations of apparently similar abundance were composed of individuals with strikingly different biological characteristics, therefore seeking relationships between abundance and environmental parameters at gross levels did not shed light on the mechanisms responsible for population size. Importantly, inter-annual differences in squid size, condition, reproductive investment, and possibly growth rate, were sex-specific, indicating that males and females responded differently to similar factors. Among years differences in body size were extreme, both among the male component of the population and between genders. The relative importance of many size-based processes that contribute to population size and structure (e.g. predation, starvation, competition, and reproductive success) will therefore vary inter-annually.