ABSTRACT
Papillary thyroid carcinoma (PTC) and cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) are head and neck tumors that share many histologic features and can be difficult to differentiate based on morphology alone. We report a case of a tongue base mass initially diagnosed as CATMSG, which after further ancillary studies, was found to be metastatic PTC. Due to the significant differences in patient management, we review the literature and recommend routine immunohistochemical testing with thyroid transcription factor-1 and thyroglobulin.
Subject(s)
Adenocarcinoma , Salivary Gland Neoplasms , Thyroid Neoplasms , Humans , Thyroid Cancer, Papillary/pathology , Salivary Glands, Minor/pathology , Adenocarcinoma/secondary , Salivary Gland Neoplasms/diagnosis , Salivary Gland Neoplasms/pathology , Tongue , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/surgery , Thyroid Neoplasms/pathologyABSTRACT
ABSTRACT: Sudden unexplained death in epilepsy (SUDEP) is the most common cause of death in children and young adults with epilepsy with epileptic patients harboring a 27 times increased risk of death from SUDEP. Structural brain lesions are encountered in up to 50% of autopsy cases. In this case series, we report 3 previously undiagnosed structural causes of SUDEP discovered at autopsy at our institution including schizencephaly, ganglioglioma, and focal cortical dysplasia. Our major recommendation is in cases with suspected SUDEP, formal neuropathological examination and tissue sampling should be employed to identify and characterize specific potential anatomic etiologies.
