Subject(s)
Activities of Daily Living/psychology , Chronic Disease/psychology , Frailty/physiopathology , Frailty/psychology , Geriatric Assessment/methods , Neoplasms/psychology , Quality of Life/psychology , Aged , Aged, 80 and over , Female , Humans , Male , Prospective Studies , Surveys and QuestionnairesABSTRACT
BACKGROUND: The incidence of postoperative complications after colorectal cancer surgery varies between publications. Complications occurring after discharge from hospital are often not reported. The aims of this study were to investigate the proportion of frail older colorectal cancer patients who developed complications only after discharge, the severity of post-discharge complications, and the time point at which the most frequent complications occurred. METHODS: Patients were included if they were 65 years and older, screened positively for frailty and were scheduled for colorectal cancer surgery. Included patients were followed prospectively both in hospital and after discharge for 30 days after surgery, and complications were graded according to the Clavien-Dindo classification. RESULTS: We included 114 patients. Median age was 79 years. Twenty-two patients (19%) were discharged without complications, but developed complications after discharge. These patients had shorter length of stay (6.5 versus 10 days), were more often discharged to their own home without assistance, and had higher 5-year survival (76% vs 54%) than patients who developed complications in hospital. Post-discharge complications were most frequently grade II. The most common types of complications that occurred late in the postoperative course were urinary tract infections and superficial surgical site infections. CONCLUSIONS: Complications after colorectal cancer surgery in frail older patients frequently arise after discharge from hospital. Doctors should be aware of this and inform their patients. This is increasingly important as length of stay after surgery decreases. When complications are used as a quality measure, it should be clear whether only in-hospital complications are registered.
Subject(s)
Colorectal Neoplasms/surgery , Frailty/diagnosis , Surgical Wound Infection/etiology , Urinary Tract Infections/etiology , Aged , Aged, 80 and over , Female , Frailty/complications , Geriatric Assessment , Humans , Length of Stay , Male , Patient Discharge , Survival Rate , Time FactorsABSTRACT
OBJECTIVE: The incidence of colorectal cancer is increasing, mainly due to the aging of the population. Frailty, describing a state of increased vulnerability, is common in older patients, but frailty and high age are not necessarily contraindications to surgical treatment. However, limited data describing long-term outcomes after surgery in this patient group exist. In this clinical follow-up study, we aimed to examine long-term health-related quality of life in older surgical patients with colorectal cancer. MATERIALS AND METHODS: Patients were recruited from a prospective multicenter study investigating frailty as a predictor of postoperative complications after surgery for colorectal cancer. A preoperative geriatric assessment was performed, and patients were classified as frail or non-frail. Patients responded to version 3.0 of The European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-C30 before surgery, 3months postoperatively and at a long-term follow-up 16-28months (median 22months) after surgery. One-way repeated-measures analyses of variance were performed to examine changes in scores over time. RESULTS: 180 patients with a mean age of 80years were included at baseline, 138 at 3months postoperatively, and 84 patients (69% of survivors) at long-term follow-up. A significant improvement in quality of life-scores was present 3months after surgery, also in the subgroup of frail patients. At long-term follow-up, scores decreased, but to values above baseline. CONCLUSION: Health-related quality of life may be improved in older patients after surgery for colorectal cancer, even in patients who are classified as frail preoperatively.
Subject(s)
Colorectal Neoplasms/surgery , Digestive System Surgical Procedures , Frailty/epidemiology , Postoperative Complications/epidemiology , Activities of Daily Living , Aged , Aged, 80 and over , Colorectal Neoplasms/epidemiology , Female , Follow-Up Studies , Frail Elderly , Geriatric Assessment , Humans , Male , Prospective Studies , Quality of LifeABSTRACT
OBJECTIVES: The number of older survivors from colorectal cancer is increasing, but little is known regarding long-term consequences of cancer treatment in this patient group. Physical function is an important outcome for older patients, affecting both autonomy and quality of life. We aimed to investigate physical function in older patients with colorectal cancer before and after surgery, and to examine the role of individual frailty indicators as predictors of functional decline. MATERIAL AND METHODS: We present 16-28 months follow-up data of older patients after elective surgery for colorectal cancer. During a home-visit, physical function was evaluated by activities of daily living (ADL), instrumental activities of daily living (IADL), the timed up-and-go (TUG) test, and grip strength. Measurements were compared with those obtained preoperatively using the Wilcoxon signed rank test. Frailty indicators were dichotomized and implemented in logistic regression models to explore their associations to a decline in the physical function scores. RESULTS: Eighty-four patients were included and the median age was 82 years. There was a significant decrease in ADL (p = 0.04) and IADL scores (p ≤ 0.001) at follow-up. We found no associations between frailty indicators and the risk of decline in physical functioning. CONCLUSION: In our population of older patients with surgically treated colorectal cancer, there was a significant decline in ADL- and IADL-scores at follow-up. No change was found in TUG or grip strength, and frailty indicators did not predict decline in physical function.
