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Transplant Proc ; 51(5): 1621-1624, 2019 Jun.
Article in English | MEDLINE | ID: mdl-31155205

ABSTRACT

Sporotrichosis is an infection caused by the fungus of the Sporothrix schenckii complex and can be particularly harmful in immunocompromised patients. We report the case of a 26-year-old male patient with a previous history of pulmonary infection who underwent a liver transplant for Budd-Chiari syndrome. After the procedure, he presented with persistent fever and leukocytosis. On the 13th post-operative day, he was diagnosed with thrombosis of the hepatic artery and underwent a second liver transplant 15 days after the first procedure. After the retransplant, he presented daily episodes of fever, even after the use of several antimicrobial, antiviral, and antifungal agents. A number of negative cultures from different sites were obtained. After an acute episode of mental confusion, the growth of S schenckii was observed in cultures from cerebrospinal fluid and ascites obtained from a diagnostic paracentesis. Treatment with amphotericin B was started but the patient died on the fourth day of antifungal treatment, from a massive gastrointestinal hemorrhage. We found no previous report in the literature of spontaneous dissemination of S schenckii to the abdominal cavity causing peritonitis.


Subject(s)
Immunocompromised Host , Liver Transplantation , Sporotrichosis/immunology , Adult , Antifungal Agents/therapeutic use , Budd-Chiari Syndrome/surgery , Fatal Outcome , Humans , Liver Transplantation/adverse effects , Male , Peritonitis/etiology
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