The First Brazilian Cardiovascular Registry of Atrial Fibrillation: Primary Results of the RECALL Study.

BACKGROUND: It is estimated that atrial fibrillation (AF) affects approximately 1.5 million people in Brazil; however, epidemiological data are limited. We sought to evaluate the characteristics, treatment patterns, and clinical outcomes in patients with AF in Brazil by creating the first nationwide prospective registry. METHODS: RECALL was a multicenter, prospective registry that included and followed for 1 year 4,585 patients with AF at 89 sites across Brazil from April 2012 to August 2019. Patient characteristics, concomitant medication use, and clinical outcomes were analyzed using descriptive statistics and multivariable models. RESULTS: Of 4,585 patients enrolled, the median age was 70 (61, 78) years, 46% were women, and 53.8% had permanent AF. Only 4.4% of patients had a history of previous AF ablation and 25.2% had a previous cardioversion. The mean (SD) CHA2DS2-VASc score was 3.2 (1.6); median HAS-BLED score was 2 (2, 3). At baseline, 22% were not on anticoagulants. Of those taking anticoagulants, 62.6% were taking vitamin K antagonists and 37.4% were taking direct oral anticoagulants. The primary reasons for not using an oral anticoagulant were physician judgment (24.6%) and difficulty in controlling (14.7%) or performing (9.9%) INR. Mean (SD) TTR for the study period was 49.5% (27.5). During follow-up, the use of anticoagulants and INR in the therapeutic range increased to 87.1% and 59.1%, respectively. The rates/100 patient-years of death, hospitalization due to AF, AF ablation, cardioversion, stroke, systemic embolism, and major bleeding were 5.76 (5.12-6.47), 15.8 (14.6-17.0), 5.0 (4.4-5.7), 1.8 (1.4-2.2), 2.77 (2.32-3.32), 1.01 (0.75-1.36), and 2.21 (1.81-2.70). Older age, permanent AF, New York Heart Association class III/IV, chronic kidney disease, peripheral arterial disease, stroke, chronic obstructive pulmonary disease, and dementia were independently associated with increased mortality while the use of anticoagulant was associated with lower risk of death. CONCLUSIONS: RECALL represents the largest prospective registry of patients with AF in Latin America. Our findings highlight important gaps in treatment, which can inform clinical practice and guide future interventions to improve the care of these patients.

Evolution of Acquired Middle Ear Cholesteatoma in Patients With Ectrodactyly, Ectodermal Dysplasia, Cleft Lip/Palate (EEC) Syndrome.

OBJECTIVE: To review an institutional experience with the surgical and clinical management of acquired middle ear cholesteatoma in patients with ectrodactyly, ectodermal dysplasia, cleft lip/palate (EEC) syndrome. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: Eight patients with medical history significant for EEC syndrome who underwent surgery for acquired middle ear cholesteatoma between 1996 and 2016. INTERVENTION(S): Appropriate surgical interventions at the time of admission. MAIN OUTCOME MEASURE(S): History of ventilation tube insertion, status of the contralateral ear, surgical technique, cholesteatoma recidivism, presence of postoperative external auditory canal stenosis, pre and postoperative audiograms. RESULTS: Cholesteatoma was diagnosed in all patients, 3 (37.5%) unilateral and 5 (62.5%) bilateral, totalizing 13 ears. Six ears (46.2%) underwent a canal wall up mastoidectomy but required conversion to a canal wall down technique in a second procedure due to recurrent cholesteatoma. In the remaining seven ears (53.8%) a canal wall down mastoidectomy was performed. Of all meatoplasty performed, seven (53.8%) evolved with stenosis of the external auditory canal. CONCLUSIONS: Our results suggest that most patients with EEC syndrome and middle ear cholesteatoma should be considered for a canal wall down mastoidectomy due to extensive disease and a high rate of recidivism. In addition, a high percentage of postoperative stenosis of the external auditory canal was found in this group.

An Implantable Hearing System As Rehabilitation for Hearing Loss Due to Bilateral Aural Atresia: Surgical Technique and Audiological Results.

OBJECTIVE: To demonstrate the surgical technique and audiological results of a middle ear implant for restoring hearing in patients with bilateral aural atresia and microtia with conductive or mixed hearing loss. MATERIALS AND METHODS: In this prospective study, 12 subjects aged 12 years and older presenting with hearing loss and bilateral congenital aural atresia underwent surgical insertion of a middle ear implant. The patients underwent tympanomastoidectomy with a wide opening of the attic and preservation of the roof of the atresic tympanic bone to expose the middle ear and position the floating mass transducer of the implant. RESULTS: There were no intraoperative or postoperative complications. The hearing threshold averages in a free field were 53.5 dB preoperatively and 25.6 dB postoperatively. Monosyllabic word recognition averaged 61% preoperatively and 91.3% postoperatively. The average speech perception in quiet conditions during the hearing in noise test improved from 67.11 dB to 45.99 dB, and the signal-to-noise ratio improved from 5.64 to 1.31. CONCLUSION: The tested system is an excellent option for auditory rehabilitation of conductive hearing loss due to bilateral ear atresia. The surgery is well structured and safe and provides several alternatives to the surgeon, which is valuable in difficult cases.

Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization / Colchicina para Redução de Fibrilação Atrial em Pós-Operatório de Revascularização Miocárdica

Abstract Background: The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality. Objective: To assess the efficacy of colchicine to prevent AF in the postoperative period of myocardial revascularization surgery, the impact of AF on hospital length of stay and death, and to identify its risk factors. Methods: Between May 2012 and November 2013, 140 patients submitted to myocardial revascularization surgery were randomized, 69 to the control group and 71 to the colchicine group. Colchicine was used at the dose of 1 mg orally, twice daily, preoperatively, and of 0.5 mg, twice daily, until hospital discharge. A single dose of 1 mg was administered to those admitted 12 hours or less before surgery. Results: The primary endpoint was AF rate in the postoperative period of myocardial revascularization surgery. Colchicine group patients showed no reduction in AF incidence as compared to control group patients (7.04% versus 13.04%, respectively; p = 0.271). There was no statistically significant difference between the groups regarding death from any cause rate (5.6% versus 10.1%; p = 0,363) and hospital length of stay (14.5 ± 11.5 versus 13.3 ± 9.4 days; p = 0.490). However, colchicine group patients had a higher infection rate (26.8% versus 8.7%; p = 0.007). Conclusion: The use of colchicine to prevent AF after myocardial revascularization surgery was not effective in the present study. Brazilian Registry of Clinical Trials number RBR-556dhr.

Resumo Fundamento: A alta prevalência de fibrilação atrial (FA) no pós-operatório de cirurgia de revascularização miocárdica ocasiona maior morbidade e mortalidade. Objetivos: Avaliar a eficácia da colchicina como profilaxia para FA no pós-operatório de cirurgia de revascularização miocárdica, o impacto da FA sobre o tempo de internação hospitalar e óbito e identificar fatores de risco para o seu aparecimento. Métodos: Entre maio de 2012 e novembro de 2013, 140 pacientes submetidos à cirurgia de revascularização miocárdica foram randomizados, 69 no grupo controle e 71 no grupo colchicina. A colchicina foi utilizada na dose de 1 mg via oral, duas vezes ao dia, no pré-operatório, e 0,5 mg, duas vezes ao dia, até a alta hospitalar. Dose única de 1 mg foi administrada aos internados 12 horas ou menos antes da cirurgia. Resultados: O desfecho primário foi a taxa de FA no pós-operatório de cirurgia de revascularização miocárdica. Os pacientes do grupo colchicina não apresentaram redução na incidência de FA em comparação aos do grupo controle (7,0% versus 13,0%, respectivamente; p = 0,271). Não houve diferença estatisticamente significativa entre os grupos em relação à taxa de óbito por qualquer causa (5,6% versus 10,1%; p = 0,363) e ao tempo de internação (14,5 ± 11,5 versus 13,3 ± 9,4 dias; p = 0,490). Porém, o grupo colchicina apresentou maior taxa de infecção (26,8% versus 8,7%; p = 0,007). Conclusões: O uso da colchicina para profilaxia da FA no pós-operatório de revascularização miocárdica não se mostrou eficaz neste estudo. Registro Brasileiro de Ensaios Clínicos número RBR-556dhr.

Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization.

BACKGROUND: The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality. OBJECTIVE: To assess the efficacy of colchicine to prevent AF in the postoperative period of myocardial revascularization surgery, the impact of AF on hospital length of stay and death, and to identify its risk factors. METHODS: Between May 2012 and November 2013, 140 patients submitted to myocardial revascularization surgery were randomized, 69 to the control group and 71 to the colchicine group. Colchicine was used at the dose of 1 mg orally, twice daily, preoperatively, and of 0.5 mg, twice daily, until hospital discharge. A single dose of 1 mg was administered to those admitted 12 hours or less before surgery. RESULTS: The primary endpoint was AF rate in the postoperative period of myocardial revascularization surgery. Colchicine group patients showed no reduction in AF incidence as compared to control group patients (7.04% versus 13.04%, respectively; p = 0.271). There was no statistically significant difference between the groups regarding death from any cause rate (5.6% versus 10.1%; p = 0,363) and hospital length of stay (14.5 ± 11.5 versus 13.3 ± 9.4 days; p = 0.490). However, colchicine group patients had a higher infection rate (26.8% versus 8.7%; p = 0.007). CONCLUSION: The use of colchicine to prevent AF after myocardial revascularization surgery was not effective in the present study. Brazilian Registry of Clinical Trials number RBR-556dhr.

Clinical and fiberoptic endoscopic evaluation of swallowing in Robin sequence treated with nasopharyngeal intubation: the importance of feeding facilitating techniques.

OBJECTIVE: To evaluate oral feeding capacity, the swallowing process, and risk for aspiration, both clinically and during fiberoptic endoscopic evaluation of swallowing, in infants with isolated Robin sequence treated exclusively with nasopharyngeal intubation and feeding facilitating techniques. DESIGN: Longitudinal and prospective study. SETTING: Hospital de Reabilitação de Anomalias Craniofaciais, University of São Paulo, Bauru, Brazil. PATIENTS: Eleven infants with isolated Robin sequence, under 2 months of age, treated with nasopharyngeal intubation. INTERVENTIONS: Feeding facilitating techniques were applied in all infants throughout the study period. The infants were evaluated clinically and through fiberoptic endoscopic evaluation of swallowing at first, second, and, if necessary, third week of hospitalization (T1, T2, T3). The mean volume of ingested milk was registered during clinical evaluation, and events were registered during feeding. RESULTS: The respiratory status of all infants was improved after nasopharyngeal intubation; 72% of them presented risk for aspiration during fiberoptic endoscopic evaluation of swallowing at T1. This risk was less frequent when thickened milk was given to the infants and at subsequent evaluations (T2 and T3). CONCLUSIONS: Nasopharyngeal intubation aids in stabilizing the airway in isolated Robin sequence, but it does not relate directly to feeding. The risk for aspiration was present in most of the infants, mainly during the first week of hospitalization, and improved within a few weeks, after the use of feeding facilitating techniques.

Otoscopic and tympanometric findings in infants with cleft lip and palate.

UNLABELLED: Tympanometry plays a fundamental role in the identification of middle ear alterations, which are frequent in the population with cleft lip and palate. AIM: do a retrospective analysis of the otoscopy and tympanometric exams of infants with cleft lip and palate who were not operated. Retrospective study. MATERIALS AND METHODS: we analyzed 273 charts from infants with cleft lip and palate whom, from March 1996 to April of 2002 underwent pneumatic otoscopy and tympanometry with a 226 Hz probe. RESULTS: We did not find statistical significance in the otoscopic and tympanometric findings considering ears and genders. We observed 84% of alterations in otoscopy (opacification/83.4%, visible fluid in the middle ear /1.5%, the ear drum does not move during inflation /1.8 and retraction/0.7) and 65% in tympanometric curves (B/38%), A/36.5%, As/21%, C/4% and Ad/0.5%). CONCLUSION: female and male infants with cleft lip and palate did not differ as far as otoscopic and tympanometry findings are concerned. All types of tympanometric curves were present, and types A and B were the most frequent ones. Ear drum opacification was the most frequent otoscopic finding. Pneumatic otoscopy identified a larger number of alterations when compared to conventional tympanometry.

Achados otoscópicos e timpanométricos em lactentes com fissura labiopalatina / Otoscopic and tympanometric findings in infants with cleft lip and palate

A timpanometria tem papel fundamental na identificação de alterações de orelha média, as quais são de grande ocorrência na população com fissura labiopalatina. OBJETIVO: Analisar de maneira retrospectiva os resultados dos exames otoscópicos e timpanométricos de lactentes com fissura labiopalatina não operados. Estudo retrospectivo. MATERIAL E MÉTODO: Foram analisados 273 prontuários de lactentes, portadores de fissura labiopalatina, submetidos de março de 1996 a abril de 2002 a otoscopia pneumática e a timpanometria com a sonda 226Hz. RESULTADOS: Não foi encontrada significância estatística nos achados otoscópicos e timpanométricos considerando os gêneros e orelhas. Observou-se 84 por cento de alteração na otoscopia (opacificação/83,4 por cento, fluido visível na orelha média/1,5 por cento, imobilidade de membrana timpânica na insuflação/1,8 e retração/0,7) e 65 por cento nas curvas timpanométricas (B/38 por cento), A/36,5 por cento, As/21 por cento, C/4 por cento e Ad/0,5 por cento). CONCLUSÃO: Os lactentes portadores de fissura labiopalatina do gênero feminino e do masculino não diferiram nas curvas timpanométricas e nos achados otoscópicos. Todos os tipos de curvas timpanométricas estiveram presentes, sendo as do tipo B e A de maior ocorrência. A opacificação de membrana timpânica foi o achado otoscópico mais freqüente. A otoscopia pneumática identificou maior número de alteração que a timpanometria convencional.

Tympanometry plays a fundamental role in the identification of middle ear alterations, which are frequent in the population with cleft lip and palate. AIM: do a retrospective analysis of the otoscopy and tympanometric exams of infants with cleft lip and palate who were not operated. Retrospective study. MATERIALS AND METHODS: we analyzed 273 charts from infants with cleft lip and palate whom, from March 1996 to April of 2002 underwent pneumatic otoscopy and tympanometry with a 226 Hz probe. RESULTS: We did not find statistical significance in the otoscopic and tympanometric findings considering ears and genders. We observed 84 percent of alterations in otoscopy (opacification/83.4 percent, visible fluid in the middle ear /1.5 percent, the ear drum does not move during inflation /1.8 and retraction/0.7) and 65 percent in tympanometric curves (B/38 percent), A/36.5 percent, As/21 percent, C/4 percent and Ad/0.5 percent). CONCLUSION: female and male infants with cleft lip and palate did not differ as far as otoscopic and tympanometry findings are concerned. All types of tympanometric curves were present, and types A and B were the most frequent ones. Ear drum opacification was the most frequent otoscopic finding. Pneumatic otoscopy identified a larger number of alterations when compared to conventional tympanometry.

[Radiofrequency catheter ablation of left accessory pathways by transeptal approach]. / Ablação por cateter com radiofreqüência de vias acessórias esquerdas por abordagem transeptal.

OBJECTIVE: To study a series of patients submitted to radiofrequency catheter ablation (RFA) of left accessory pathways (AP) using the transeptal approach (TSA) as compared to the conventional retrograde arterial approach (RAA). METHODS: One hundred consecutive patients (56 male; mean age of 34.3 +/- 11 years) with 100 left APs (62 overt and 38 concealed) underwent catheter ablation using the TS method (50 patients) and the RA method (50 patients) in an alternate fashion. The analysis was performed according to the intention-to-treat principle. RESULTS: The transeptal puncture was successfully performed in 48 patients (96%). This access allowed primary success in the ablation in all the patients without any complication. When we compared this approach with the RAA there was no difference as regards the primary success (p = 0.2), recurrence rate (p = 1.0), fluoroscopy time (p = 0.63) and total time (p = 0.47). One patient in the RAA group presented a vascular complication. The TSA allowed shorter ablation times (p=0.01) and smaller number of radiofrequency applications (p = 0.003) as compared to the conventional RAA. The patients who had recurrence and unsuccessful ablation in the first session in each approach underwent another session with the opposite technique (cross-over), with a final ablation success rate of 100%. CONCLUSION: The TS and RA approaches showed similar efficacy and safety for the ablation of left accessory pathways. The TSA allowed shorter ablation times and smaller number of radiofrequency applications. When the techniques were used in a complementary fashion, they increased the final efficacy of the ablation.

Ablação por cateter com radiofreqüência de vias acessórias esquerdas por abordagem transeptal / Radiofrequency catheter ablation of left accessory pathways by transeptal approach

OBJETIVO: Estudar uma série de pacientes submetidos a ablação por cateter, com radiofreqüência (RF) de vias acessórias (VA) esquerdas mediante abordagem transeptal (TS), comparando-os aos pacientes submetidos ao mesmo tipo de procedimento por abordagem arterial retrógrada (AR) convencional. MÉTODOS: Cem pacientes consecutivos (56 masculinos; 34,3 ± 11 anos de idade), portadores de 100 VA esquerdas (62 manifestas e 38 ocultas) foram submetidos a ablação por cateter por via TS (50 pacientes) e por via AR (50 pacientes), de forma alternada. A análise foi baseada na intenção de tratar. RESULTADOS: A punção transeptal foi realizada com sucesso em 48 (96 por cento) pacientes. Por esse acesso foi obtido sucesso primário na ablação em todos os pacientes e nenhuma complicação foi observada. Ao compararmos com o grupo AR não verificamos diferença em relação ao sucesso primário (p = 0,2), taxa de recorrências (p = 1,0), tempos de fluoroscopia (p = 0,63) e total (p = 0,47). No grupo AR um paciente apresentou complicação vascular. A abordagem TS proporcionou um menor tempo de ablação (p = 0,01) e número de aplicações de RF (p = 0,003) em relação à abordagem AR convencional. As recorrências e insucessos da primeira sessão de cada grupo foram submetidos a novo procedimento pela técnica oposta (cross-over), obtendo-se assim um sucesso final na ablação de 100 por cento. CONCLUSÃO: As abordagens TS e AR apresentam eficácia e segurança semelhantes para ablação de vias acessórias esquerdas. O tempo de ablação e o número de aplicações de RF foram menores com a abordagem TS. Quando as técnicas foram utilizadas de forma complementar, aumentaram a eficácia final da ablação.

Catheter ablation of atriofascicular Mahaim fibers guided by the activation potential.

OBJECTIVE: To determine whether recording of the activation potential may be used as an isolated criterion to guide catheter ablation of atriofascicular Mahaim fibers. METHODS: We studied 6 patients (5 females, mean age of 26 +/- 7.3 years) with paroxysmal tachycardias with a wide QRS complex, whose electrophysiological study diagnosed atriofascicular Mahaim fibers. Mapping and catheter ablation were performed in sinus rhythm, guided only by the recording of the activation potential of the fiber. RESULTS: Efficacy in ablation was achieved in all patients. The fibers were located in the right lateral region of the tricuspid ring in 3 patients, right posterolateral region in 2, and right anterolateral region in 1. A mean of 5.3 +/- 3 radiofrequency applications was performed. The mean fluoroscopy time was 46.6 +/- 25 minutes, and the mean duration of the procedure was 178.6 +/- 108 minutes. No complication occurred. In a mean 20-month follow-up, all patients were asymptomatic and receiving no antiarrhythmic drugs. CONCLUSION: Catheter ablation of Mahaim fibers may be performed with good safety and efficacy by mapping the activation potential of the tricuspid ring in sinus rhythm.

Ablaçäo por cateter de fibras atriofasciculares de Mahaim guiada pelo potencial de ativaçäo / Catheter ablation of atriofascicular Mahaim fibers guided by the activation potential

OBJECTIVE: To determine whether recording of the activation potential may be used as an isolated criterion to guide catheter ablation of atriofascicular Mahaim fibers. METHODS: We studied 6 patients (5 females, mean age of 26±7.3 years) with paroxysmal tachycardias with a wide QRS complex, whose electrophysiological study diagnosed atriofascicular Mahaim fibers. Mapping and catheter ablation were performed in sinus rhythm, guided only by the recording of the activation potential of the fiber. RESULTS: Efficacy in ablation was achieved in all patients. The fibers were located in the right lateral region of the tricuspid ring in 3 patients, right posterolateral region in 2, and right anterolateral region in 1. A mean of 5.3±3 radiofrequency applications was performed. The mean fluoroscopy time was 46.6±25 minutes, and the mean duration of the procedure was 178.6±108 minutes. No complication occurred. In a mean 20-month follow-up, all patients were asymptomatic and receiving no antiarrhythmic drugs. CONCLUSION: Catheter ablation of Mahaim fibers may be performed with good safety and efficacy by mapping the activation potential of the tricuspid ring in sinus rhythm

Procedimentos ablativos por cateter no tratamento da fibrilaçäo atrial / Catheter ablation for the treatment of atrial fibrillation

A alta prevalência da fibrilaçäo atrial, assim como sua morbidade e mortalidade, a ausência de terapêutica farmacológica segura e efetiva, e o entendimento cada vez maior de suas bases fisiopatológicas, tem estimulado o desenvolvimento de terapêuticas näo farmacológicas para a abordagem desta arritmia. Nos pacientes que apresentam fibrilaçäo atrial com alta resposta ventricular e refratária a drogas, a ablaçäo da junçäo AV, com implante de marcapasso, tem se mostrado uma alternativa efetiva, no entanto, restrita ao controle da freqüência cardíaca. A modificaçäo do nó AV pode ser utilizada como primeira tentativa para o controle da freqüência, antes da opçäo definitva, representada pela ablaçäo da junçäo AV. As técnicas propostas de ablaçäo por cateter, baseadas na cirurgia de Cox, carecem de maior esclarecimentos da fisiopatologia da fibrilaçäo atrial, assim como de avanços tecnológicos relacionados aos cateteres e as novas fontes de energia, para que se desenvolvam técnicas mais eficazes, seguras, e de maior aplicabilidade prática. A ablaçäo de focos deflagradores da fibrilaçäo atrial, embora em fase de investigaçäo em relaçäo a sua real eficácia e margem de complicaçöes, traz a expectativa de cura da chamada fibrilaçäo atrial focal

Caracterizaçäo das alteraçöes miofuncinais orais e auditivas em indivíduos com disfunçäo craniomandibular / Characterization of oral and auditory functions in subjects with craniomandibular disorders

O presente estudo buscou caracterizar os sintomas miofuncionais orais e auditivos de 11 indivíduos com disfunçäo craniomandibular (DCM), por meio de entrevista e avaliaçäo fonoaudiológica e otorrinolaringológica. Os resultados obtidos mostraram alteraçöes nas funçöes de mastigaçäo, deglutiçäo, respiraçäo, fonoarticulaçäo e audiçäo

Pigmentaçäo bucal e anemia: apresentaçäo de um caso / Oral pigmentation and anemia: report of a case

Os autores apresentam o caso de um paciente de 35 anos do sexo masculino, branco que apresentava lesöes pigmentadas orais associadas a disfagia, cujo único fator predisponente era anemia ferropriva de longa data, secundária e gastrectomia. O caso reveste-se de interese pela sua particularidade, assim como pelo diagnóstico diferencial com outras patologias, além do tempo necessário para identificar-se a etiologia