Redesigning Today's Driving Automation Toward Adaptive Backup Control With Context-Based and Invisible Interfaces.

OBJECTIVE: We investigated a driver monitoring system (DMS) designed to adaptively back up distracted drivers with automated driving. BACKGROUND: Humans are likely inadequate for supervising today's on-road driving automation. Conversely, backup concepts can use eye-tracker DMS to retain the human as the primary driver and use computerized control only if needed. A distraction DMS where perceived false alarms are minimized and the status of the backup is unannounced might reduce problems of distrust and overreliance, respectively. Experimental research is needed to assess the viability of such designs. METHODS: In a driving simulator, 91 participants either supervised driving automation (auto-hand-on-wheel vs. auto-hands-off-wheel), drove with different forms of DMS-induced backup control (eyes-only-backup vs. eyes-plus-context-backup; visible-backup vs. invisible-backup), or drove without any automation. All participants performed a visual N-back task throughout. RESULTS: Supervised driving automation increased visual distraction and hazard non-responses compared to backup and conventional driving. Auto-hand-on-wheel improved response generation compared to auto-hands-off-wheel. Across entire driving trials, the backup improved lateral performance compared to conventional driving. Without negatively impacting safety, the eyes-plus-context-backup DMS reduced unnecessary automated control compared to the eyes-only-backup DMS conditions. Eyes-only-backup produced low satisfaction ratings, whereas eyes-plus-context-backup satisfaction was on par with automated driving. There were no appreciable negative consequences attributable to the invisible-backup driving automation. CONCLUSIONS: We have demonstrated preliminary feasibility of DMS designs that incorporate driving context information for distraction assessment and suppress their status indication. APPLICATION: An appropriately designed DMS can enable benefits for automated driving as a backup.

Blood donor screening with cobas s 201/cobas TaqScreen MPX under routine conditions at German Red Cross institutes.

BACKGROUND: In 1997 the German Red Cross (GRC) blood donor services introduced mini-pool nucleic acid testing (NAT) for human immunodeficiency virus (HIV)-1, hepatitis C virus (HCV) and hepatitis B virus (HBV) to increase blood safety. With the new cobas s 201/cobas TaqScreen MPX, a fully automated extraction method and a multiplex amplification system specifically adapted to the needs of blood donation services is available. METHODS: The cobas s 201 system was evaluated at the GRC BTS locations Hagen, Springe and Frankfurt. In phase A, the analytical sensitivity for the detection of HBV, HCV and HIV-1 was investigated and in phase B, at least 60,000 samples at each test site were screened in parallel with the MPX test on s 201 system and the existing routine mini-pool NAT system to compare the diagnostic specificity and the diagnostic sensitivity. RESULTS: Comparable analytical sensitivities in a range of 1.6-3.6 IU/ml, 4.9-10.9 IU/ml and 14.7-26.6 IU/ml for HBV, HCV HIV, respectively, for the MPX test on s 201 system (95% probability based on probit analysis) were determined at all test sites. The diagnostic sensitivity was 99.8% and the diagnostic specificity was 99.85%. CONCLUSIONS: The MPX test on s 201 system is a fully automated NAT system suitable for routine blood donor screening. The analytical sensitivity as well as the diagnostic sensitivity fulfilled all requirements of the Paul Ehrlich Institute for blood donor screening in mini-pools up to 96 donations per pool. A major benefit of the automated NAT system is the reduced personnel time and the extensive complete barcode-controlled process documentation.