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J Exp Clin Cancer Res ; 18(3): 325-9, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10606177

ABSTRACT

The effect of an indigenous medical preparation--Brahma Rasayana (BR)--on the haemopoetic protection in cancer patients undergoing radio in association with chemotherapy was studied. Administration of BR accelerated the recovery of the haemopoetic system as seen by a rapid rise in total leukocytes. Both lymphocytes and neutrophils were significantly increased by Rasayana treatment. Nadir of WBC was 3633 +/- 120 and 2954 +/- 305 in treated and untreated patients. Nadir of neutrophils was 2830 +/- 964 in treated patients and 1791 +/- 922 in untreated patients. Nadir of lymphocytes remained almost unchanged. Total number of consecutive days of leukopenia, neutropenia and lymphopenia was also significantly reduced after the treatment. Rasayana treatment also made serum lipid peroxidation decrease confirming its capacity of reducing oxidative stress induced by cancer treatment. The use of this non-toxic preparation as an adjuvant in cancer therapy will prove out to be highly beneficial.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antioxidants/therapeutic use , Bone Marrow/drug effects , Leukopenia/prevention & control , Neoplasms/drug therapy , Plant Extracts/therapeutic use , Radiation Injuries/prevention & control , Radiotherapy/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Antioxidants/pharmacology , Bone Marrow/radiation effects , Chemotherapy, Adjuvant , Cisplatin/administration & dosage , Cisplatin/adverse effects , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Etoposide/administration & dosage , Etoposide/adverse effects , Female , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Granulocyte-Macrophage Colony-Stimulating Factor/blood , Hematopoietic Stem Cells/drug effects , Humans , India , Leukocyte Count/drug effects , Leukopenia/chemically induced , Leukopenia/etiology , Lipid Peroxidation/drug effects , Male , Mitoxantrone/administration & dosage , Mitoxantrone/adverse effects , Neoplasms/radiotherapy , Pharmaceutical Preparations/administration & dosage , Pilot Projects , Plant Extracts/administration & dosage , Plant Extracts/pharmacology , Radiation Injuries/etiology
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