ABSTRACT
ABSTRACT: Acute hemorrhagic leukoencephalitis (AHL) is an acute, hemorrhagic demyelinating disease thought to be caused by an immune-mediated process. Acute hemorrhagic leukoencephalitis is both diagnostically challenging and fatal in the majority of cases. We present two cases of AHL unexpectedly diagnosed at autopsy. These cases demonstrate the often nonspecific and challenging nature of AHL clinical presentation, review neuropathological mimics, and emphasize the importance of considering this diagnosis in the forensic setting.
Subject(s)
Leukoencephalitis, Acute Hemorrhagic/diagnosis , Adolescent , Brain/pathology , Fatal Outcome , Female , Humans , Male , Middle AgedSubject(s)
Bile Duct Neoplasms/diagnosis , Cholangiocarcinoma/diagnosis , Cholangitis, Sclerosing/diagnosis , Immunoglobulin G/immunology , Bile Duct Neoplasms/surgery , Bile Ducts, Intrahepatic , Biopsy, Needle , Cholangiocarcinoma/surgery , Cholangiopancreatography, Endoscopic Retrograde/methods , Cholangitis, Sclerosing/surgery , Decompression, Surgical/methods , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Immunohistochemistry , Jaundice, Obstructive/diagnosis , Jaundice, Obstructive/etiology , Laparoscopy/methods , Magnetic Resonance Imaging/methods , Middle Aged , Tomography, X-Ray Computed/methods , Treatment Outcome , Ultrasonography, DopplerABSTRACT
We report the synthesis and structural characterization of a dicobalt(III) complex with a µ-OH,µ-O2 core, namely µ-OH,µ-O2-[Co(enN4)]2(X)3 [1(ClO4)3 and 1(BF4)3]. The dinuclear core is cross-linked by two N4 Schiff base ligands that span each cobalt center. The formally Co(III)-Co(III) dimer is formed spontaneously upon exposure of the mononuclear Co(II) complex to air and exhibits a ν(O-O) value at 882 cm(-1) that shifts to 833 cm(-1) upon substitution with (18)O2. The CV of 1(BF4)3 exhibits a reversible {Co(III)-Co(III)}â{Co(III)-Co(IV)} redox process, and we have investigated the oxidized {Co(III)-Co(IV)} species by EPR spectroscopy (g = 2.02, 2.06; S = 1/2 signal) and DFT calculations.
