Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial.

OBJECTIVE: To evaluate whether race or ethnicity was independently associated with parental refusal of consent for their child's participation in a multisite pediatric critical care clinical trial. STUDY DESIGN: We performed a secondary analyses of data from Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE), a 31-center cluster randomized trial of sedation management in critically ill children with acute respiratory failure supported on mechanical ventilation. Multivariable logistic regression modeling estimated associations between patient race and ethnicity and parental refusal of study consent. RESULT: Among the 3438 children meeting enrollment criteria and approached for consent, 2954 had documented race/ethnicity of non-Hispanic White (White), non-Hispanic Black (Black), or Hispanic of any race. Inability to approach for consent was more common for parents of Black (19.5%) compared with White (11.7%) or Hispanic children (13.2%). Among those offered consent, parents of Black (29.5%) and Hispanic children (25.9%) more frequently refused consent than parents of White children (18.2%, P < .0167 for each). Compared with parents of White children, parents of Black (OR 2.15, 95% CI 1.56-2.95, P < .001) and Hispanic (OR 1.44, 95% CI 1.10-1.88, P = .01) children were more likely to refuse consent. Parents of children offered participation in the intervention arm were more likely to refuse consent than parents in the control arm (OR 2.15, 95% CI 1.37-3.36, P < .001). CONCLUSIONS: Parents of Black and Hispanic children were less likely to be approached for, and more frequently declined consent for, their child's participation in a multisite critical care clinical trial. Ameliorating this racial disparity may improve the validity and generalizability of study findings. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00814099.

Frequent vaccination missed opportunities at primary care encounters contribute to underimmunization.

OBJECTIVE: To examine missed opportunities to administer an eligible vaccination (MOs) and their contribution to underimmunization in contemporary pediatric practices. STUDY DESIGN: This study was a retrospective analysis from 42 diverse pediatric practices located throughout the US. Medical records of 50 randomly selected children 3-18 months of age per practice were reviewed in Spring 2013. Immunization status for age and MOs were assessed as of each encounter and as of March 1, 2013. RESULTS: Of 2076 eligible patients, 72.7% (95% CI 67.6-77.9) were up-to-date with receipt of standard vaccines. Most children (82.4%; 95% CI 78.3-85.9) had at least 1 MO, and 37.8% (95% CI 30.0-46.2) had at least one MO to administer an overdue vaccination. After adjustment, risk of underimmunization was 3.5 times greater for patients who had ever experienced an MO for an overdue vaccination compared with those who had not (adjusted relative risk = 3.5; 95% CI 2.8-4.3). If all age-appropriate vaccinations had been administered at the last recorded encounter, 45.5% (95% CI 36.8-54.5) of the underimmunized patients would have been up to date at the time of assessment. CONCLUSION: MOs were common and contributed substantially to underimmunization in this contemporary sample of diverse primary care practice settings.

African-American parents' perceptions of partnership with their child's primary care provider.

OBJECTIVE: To identify family, provider, and healthcare setting characteristics associated with African-American parents' perceptions of partnership with their child's primary care provider. STUDY DESIGN: Data were collected via a telephone survey of 425 African-American parents of 0- to 5-year-old children who had presented for a health visit 1 to 2 weeks earlier at participating pediatric primary care practices in Washington, DC. Parents' perceptions of the level of partnership building by their child's provider were assessed using the Street Provider Communication Style instrument. RESULTS: Multivariate logistic regression models indicated that, after adjusting for other family and provider/setting characteristics, parents seen in community health centers were more likely to report high partnership building compared with parents seen at private or hospital-based practices. Parents with at least a college education and those who described their child's provider's race as "other" were most likely to report moderate partnership building. CONCLUSIONS: Future studies should examine elements of care delivery at community health centers that may lead to better partnerships between parents and providers in private and hospital-based practice settings.

Central American adolescent acculturation and parental distress: relationship to ratings of adolescent behavior problems.

This study examined the relationship of acculturation and Central American adolescents' behavioral problems as reported by their parents. Cross-sectional survey data regarding demography, acculturation, and psychosocial functioning was examined among 112 urban adolescent immigrants, aged 12 to 17 years. Analysis indicated that, when parents and adolescents differed in acculturation, parents most frequently rated their adolescent with internalizing symptoms at a clinically elevated level. Parents' education and distress predicted parents' reports of adolescents' psychosocial problems beyond demographic factors, respondents' characteristics, and parents' and adolescents' acculturation. Higher relative acculturation among adolescents, but not parents, was the most robust predictor of parental distress scores, indicating that parental distress mediates the relationship between high relative acculturation of the adolescents and their psychosocial problems as reported by parents. Implications for research and clinicians conducting mental health interventions with Central American populations are briefly discussed.