ABSTRACT
This systematic review explores the release and health outcomes of exposure to chalk particles in classrooms. A literature search was conducted on Scopus, Google Scholar, and the Web of Science. Chalk particles contribute significantly to poor indoor air quality in classrooms. Higher concentrations of PM2.5 chalk particles were found in the front row (14.25 µg/m3) and near the chalkboard (19.07 µg/m3). Inhalation and dermal are significant exposure routes; hence, teachers and learners are at risk of developing respiratory and skin disorders. Inhalation of chalk particles correlates with reduced lung function in teachers and learners. The release and size of chalk particles depend on the activities, type of chalk sticks, and texture of the chalkboards. Wiping the chalkboard releases more chalk particles of smaller size (3.85-9.3 µm) than writing (10.57-92.91 µm). A shift from chalk sticks and chalkboards in classrooms is necessary to mitigate the associated health risks.
ABSTRACT
Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing convalescent plasma derived exosomes (CPExo) from COVID-19 recovered persistence could accelerate the treatment strategies in the current state of affairs. Adequate literature has shown that administering the exosome to the in vivo system could be beneficial and could target the pathogens in an effective and precise manner. In this hypothesis we highlight the CPExo instead of convalescent plasma (CP), perhaps to dispense of exosomes are gratified and it's more effectively acquired immune response conferral through antibodies. COVID-19 convalescent plasma has billions of exosomes and it has aptitudes to carry molecular constituents like proteins, lipids, RNA and DNA, etc. Moreover, exosomes are capable of recognizing antigens with adequate sensitivity and specificity. Many of these derivatives could trigger an immune modulation into the cells and act as an epigenetic inheritor response to target pathogens through RNAs. COIVID-19 resistance activated plasma-derived exosomes are either responsible for the effects of plasma beyond the contained immune antibodies or could be inhibitory. The proposed hypothesis suggests that preselecting the plasma-derived antibodies and RNAs merged exosomes would be an optimized therapeutic tactic for COVID-19 patients. We suggest that, the CPExo has a multi-potential effect for treatment efficacy by acting as immunotherapeutic, drug carrier, and diagnostic target with noncoding genetic materials as a biomarker.
