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1.
Nature ; 624(7992): 539-544, 2023 Dec.
Article in English | MEDLINE | ID: mdl-38030731

ABSTRACT

Entanglement is a distinguishing feature of quantum many-body systems, and uncovering the entanglement structure for large particle numbers in quantum simulation experiments is a fundamental challenge in quantum information science1. Here we perform experimental investigations of entanglement on the basis of the entanglement Hamiltonian (EH)2 as an effective description of the reduced density operator for large subsystems. We prepare ground and excited states of a one-dimensional XXZ Heisenberg chain on a 51-ion programmable quantum simulator3 and perform sample-efficient 'learning' of the EH for subsystems of up to 20 lattice sites4. Our experiments provide compelling evidence for a local structure of the EH. To our knowledge, this observation marks the first instance of confirming the fundamental predictions of quantum field theory by Bisognano and Wichmann5,6, adapted to lattice models that represent correlated quantum matter. The reduced state takes the form of a Gibbs ensemble, with a spatially varying temperature profile as a signature of entanglement2. Our results also show the transition from area- to volume-law scaling7 of von Neumann entanglement entropies from ground to excited states. As we venture towards achieving quantum advantage, we anticipate that our findings and methods have wide-ranging applicability to revealing and understanding entanglement in many-body problems with local interactions including higher spatial dimensions.

2.
Nature ; 621(7980): 740-745, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37648868

ABSTRACT

The control over quantum states in atomic systems has led to the most precise optical atomic clocks so far1-3. Their sensitivity is bounded at present by the standard quantum limit, a fundamental floor set by quantum mechanics for uncorrelated particles, which can-nevertheless-be overcome when operated with entangled particles. Yet demonstrating a quantum advantage in real-world sensors is extremely challenging. Here we illustrate a pathway for harnessing large-scale entanglement in an optical transition using 1D chains of up to 51 ions with interactions that decay as a power-law function of the ion separation. We show that our sensor can emulate many features of the one-axis-twisting (OAT) model, an iconic, fully connected model known to generate scalable squeezing4 and Greenberger-Horne-Zeilinger-like states5-8. The collective nature of the state manifests itself in the preservation of the total transverse magnetization, the reduced growth of the structure factor, that is, spin-wave excitations (SWE), at finite momenta, the generation of spin squeezing comparable with OAT (a Wineland parameter9,10 of -3.9 ± 0.3 dB for only N = 12 ions) and the development of non-Gaussian states in the form of multi-headed cat states in the Q-distribution. We demonstrate the metrological utility of the states in a Ramsey-type interferometer, in which we reduce the measurement uncertainty by -3.2 ± 0.5 dB below the standard quantum limit for N = 51 ions.

3.
Phys Rev Lett ; 124(24): 240505, 2020 Jun 19.
Article in English | MEDLINE | ID: mdl-32639800

ABSTRACT

In ergodic many-body quantum systems, locally encoded quantum information becomes, in the course of time evolution, inaccessible to local measurements. This concept of "scrambling" is currently of intense research interest, entailing a deep understanding of many-body dynamics such as the processes of chaos and thermalization. Here, we present first experimental demonstrations of quantum information scrambling on a 10-qubit trapped-ion quantum simulator representing a tunable long-range interacting spin system, by estimating out-of-time ordered correlators (OTOCs) through randomized measurements. We also analyze the role of decoherence in our system by comparing our measurements to numerical simulations and by measuring Rényi entanglement entropies.

4.
Phys Rev Lett ; 124(1): 010504, 2020 Jan 10.
Article in English | MEDLINE | ID: mdl-31976701

ABSTRACT

We describe a protocol for cross-platform verification of quantum simulators and quantum computers. We show how to measure directly the overlap Tr[ρ_{1}ρ_{2}] and the purities Tr[ρ_{1,2}^{2}], and thus a fidelity of two, possibly mixed, quantum states ρ_{1} and ρ_{2} prepared in separate experimental platforms. We require only local measurements in randomized product bases, which are communicated classically. As a proof of principle, we present the measurement of experiment-theory fidelities for entangled 10-qubit quantum states in a trapped ion quantum simulator.

5.
J Nutr Biochem ; 24(3): 595-605, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22819553

ABSTRACT

Consumption of tea (Camellia sinensis) improves vascular function and is linked to lowering the risk of cardiovascular disease. Endothelial nitric oxide is the key regulator of vascular functions in endothelium. In this study, we establish that l-theanine, a non-protein amino-acid found in tea, promotes nitric oxide (NO) production in endothelial cells. l-theanine potentiated NO production in endothelial cells was evaluated using Griess reaction, NO sensitive electrode and a NO specific fluorescent probe (4-amino-5-methylamino-2',7'-difluororescein diacetate). l-Theanine induced NO production was partially attenuated in presence of l-NAME or l-NIO and completely abolished using eNOS siRNA. eNOS activation was Ca(2+) and Akt independent, as assessed by fluo-4AM and immunoblotting experiments, respectively and was associated with phosphorylation of eNOS Ser 1177. eNOS phosphorylation was inhibited in the presence of ERK1/2 inhibitor, PD-98059 and partially inhibited by PI3K inhibitor, LY-294002 and Wortmanin suggesting PI3K-ERK1/2 dependent pathway. Increased NO production was associated with vasodilation in ex ovo (chorioallantoic membrane) model. These results demonstrated that l-theanine administration in vitro activated ERK/eNOS resulting in enhanced NO production and thereby vasodilation in the artery. The results of our experiments are suggestive of l-theanine mediated vascular health benefits of tea.


Subject(s)
Endothelial Cells/drug effects , Glutamates/pharmacology , Nitric Oxide Synthase Type III/genetics , Nitric Oxide/biosynthesis , Plant Extracts/pharmacology , Apoptosis/drug effects , Calcium/analysis , Calcium/metabolism , Cell Line , Cell Survival/drug effects , Chromones/pharmacology , Endothelial Cells/metabolism , Endothelium, Vascular/cytology , Endothelium, Vascular/drug effects , Flavonoids/pharmacology , Humans , Mitogen-Activated Protein Kinase 1/antagonists & inhibitors , Mitogen-Activated Protein Kinase 1/genetics , Mitogen-Activated Protein Kinase 1/metabolism , Mitogen-Activated Protein Kinase 3/antagonists & inhibitors , Mitogen-Activated Protein Kinase 3/genetics , Mitogen-Activated Protein Kinase 3/metabolism , Morpholines/pharmacology , NG-Nitroarginine Methyl Ester/metabolism , Nitric Oxide Synthase Type III/metabolism , Ornithine/analogs & derivatives , Ornithine/metabolism , Phosphatidylinositol 3-Kinases/genetics , Phosphatidylinositol 3-Kinases/metabolism , Phosphorylation , Proto-Oncogene Proteins c-akt/genetics , Proto-Oncogene Proteins c-akt/metabolism , Signal Transduction , Tea/chemistry , Vasodilation/drug effects
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