Palladium anchored to BisPyP@bilayer-SiO2@NMP organic-inorganic hybrid as an efficient and recoverable novel nanocatalyst in suzuki and stille C-C coupling reactions.

The palladium anchored to BisPyP@bilayer-SiO2@NMP organic-inorganic hybrid was employed as an effective and recyclable organometallic catalyst in Suzuki and Stille C-C coupling reactions. The structure of this magnetic nanocatalyst was determined using various techniques such as SEM, TEM, FT-IR, EDS, ICP-OES, VSM, N2 adsorption-desorption isotherms, XRD, and TGA. In both of the mentioned coupling paths, the yields of the products were very favorable and ranged from 90 to 98%. Also, they had significant features compared to previous reports, such as very short reaction time (5-15 and 7-20 min respectively in the Suzuki and Stille reactions), easy work-up, broad substrate scope, ease of separation of the catalyst using a magnet, suitable reproducibility of the catalyst in 6 runs, heterogeneous nature of the catalyst and not washing it during consecutive runs with confirmation of hot filtration and ICP-OES methods.

Multi­objective optimization of nitrile rubber and thermosets modified bituminous mix using desirability approach.

A variety of materials, including waste and rubber products, have been used in road construction to improve the performance of bituminous pavements. The present investigation is focused on modifying bitumen using Nitrile rubber (NBR) with different thermosets namely Bakelite (B), Furan Resin (FR), and Epoxy resin (ER). The emphasis of the problem is to arrive at a mix to achieve maximum Marshall Stability (MS) and minimum flow value of Modified Bituminous Concrete. Taguchi DOE technique has been used to design the experiments using Minitab software. Analysis of Variance (ANOVA) and Multi-objective optimization has been performed using the desirability approach in Design expert software. ANOVA analysis predicts that NBR, B, ER, and FR are the major significant parameters for Marshall Stability (MS) and Flow Value (FV). It has also been analyzed from SEM and EDS images of modified bitumen that sample S1 (5% NBR, 10% Bakelite, 10% FR, 2.5% ER) has a fine surface with small pores as compared to sample S34 (10% NBR, 0% Bakelite 10% FR, 2.5% ER). Multi-optimization results suggested the optimal conditions are achieved at NBR-7.6%, Bakelite-4.8%, FR-2.5%, and ER-2.6% for MS and FV. The maximum MS is 14.84 KN and the minimum FV is 2.84 mm is obtained using optimum conditions. To validate the optimization results, the confirmation runs have been conducted, and obtained results are within 5% error with optimal conditions.

Squamous odontogenic tumor with unusual localization and appearance: a rare case report.

Squamous odontogenic tumor is a rare benign neoplasm and may affect multiple sites in the mouth. SOT was first described by Pullon et al. (1975). Since then, there have been less than 50 reported cases. The tumor is often asymptomatic, although it can present with symptoms of pain and tooth mobility. We report a case of SOT occurring in a 26-year-old female in the anterior mandible with unusual localization and appearance.

A comparative study of p53 expression in hyperplastic, dysplastic epithelium and oral squamous cell carcinoma

Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to determine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. Methods: Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining forhistopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. p53 positivity was looked for in each IHC stained slide and the number of positive cells amongst 1,000 epithelial cells were recorded. The localization of these p53 positive cells within the strata (i.e.basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also with ineach group according to histological grades was recorded. Results: Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelialcells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells. Conclusions: Qualitatively p53 is not a specific marker for malignancy of oral epithelium. However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma.