ABSTRACT
The Raman and ir spectra of a murine IgG2a monoclonal antibody molecule are reported. In accordance with previous studies on immunoglobulins, the secondary structure is predominantly of the beta-sheet type. The low frequency region of the Raman spectrum was also analyzed in detail. A structured band with two maxima near 43 and 94 cm(-1) was observed. This band has been attributed to vibrations of elastic body. The results are interpreted using a simple elastic model.
Subject(s)
Immunoglobulin G/chemistry , Spectrophotometry, Infrared/methods , Spectrum Analysis, Raman/methods , Animals , Antibodies, Monoclonal/chemistry , Mice , Mice, Inbred BALB C , Protein Structure, SecondaryABSTRACT
We report nine cases of haemophagocytic syndrome (HS) in patients with human immunodeficiency virus infection, and review the 17 cases described to date in the literature. In 21 of 26 cases, HS developed during an advanced stage of immunodeficiency. Clinical and haematological signs are not specific in this setting, and the diagnosis relies on histological features, mainly bone marrow examination. An opportunistic infection was associated in three cases and a lymphoid malignancy in two of our nine cases. The role of the human immunodeficiency virus in the occurrence of the HS remains to be defined. The overall prognosis is poor as six of our nine patients died within 12 months of presentation.
Subject(s)
HIV Infections/complications , Histiocytosis, Non-Langerhans-Cell/etiology , Adult , Biopsy , Bone Marrow/pathology , Female , Histiocytosis, Non-Langerhans-Cell/pathology , Humans , Male , Middle Aged , Skin/pathologyABSTRACT
The toxic effects of daunorubicin with specific reference to acute, subacute, and long-term studies in animals are reviewed, and its clinical toxicity is considered. We emphasize the importance of hematologic toxicity and infections when treating with daunorubicin. A summary of the work done on detoxifying activities of certain compounds is presented, and the activities that increase the toxic effects of daunorubicin are discussed. Finally, the immunosuppressive, mutagenic, teratogenic, and carcinogenic activities of daunorubicin are mentioned.
