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1.
Vaccines (Basel) ; 11(1)2022 Dec 22.
Article in English | MEDLINE | ID: mdl-36679871

ABSTRACT

(1) Background: COVID-19 vaccination in Brazil has been performed mostly with CoronaVac (Sinovac), ChAdOx1-S (AstraZeneca-University of Oxford) and BNT162b2 (Pfizer-BioNTech) vaccines. The titers of IgG antibodies reactive to the SARS-CoV-2 spike protein correlate with vaccine efficacy. Studies comparing vaccine immunogenicity in a real-world scenario are lacking. (2) Methods: We performed a population-based study to analyze the immunoglobulin G response to different COVID-19 vaccines. Citizens older than 18 years (n = 2376) provided personal data, a self-declaration of any previous COVID-19 positive tests and information regarding COVID-19 vaccination: the vaccine popular name and the date of each dose. Blood samples were collected and the levels of IgG reactive to SARS-CoV-2 antigens were determined and compared between different vaccine groups. (3) Results: The seroconversion for anti-spike IgG achieved > 95% by February 2022 and maintained stable until June 2022. Higher anti-spike IgG titers were detected in individuals vaccinated with BNT162b2, followed by ChAdOx1-S and CoronaVac. The anti-spike IgG response was negatively correlated with age and interval after the second dose for the BNT162b2 vaccine. Natural infections boosted anti-spike IgG in those individuals who completed primary vaccination with ChAdOx1-S and CoronaVac, but not with BNT162b2. The levels of anti-spike IgG increased with the number of vaccine doses administered. The application of BNT162b2 as a 3rd booster dose resulted in high anti-spike IgG antibody titers, despite the type of vaccine used during primary vaccination. (4) Conclusions: Our data confirmed the effectiveness of the Brazilian vaccination program. Of the vaccines used in Brazil, BNT162b2 performed better to elicit anti-spike protein IgG after primary vaccination and as a booster dose and thus should be recommended as a booster whenever available. A continuous COVID-19 vaccination program will be required to sustain anti-spike IgG antibodies in the population.

2.
Fisioter. mov ; 25(4): 785-794, out.-dez. 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-660500

ABSTRACT

INTRODUÇÃO: Com a finalidade de investigar a etiologia dos sintomas osteomusculares em professores, estudos tem abordado a relação entre o trabalho docente e as possíveis particularidades da profissão que podem levar ao adoecimento físico dos professores. OBJETIVO: Analisar os sintomas osteomusculares de professores do ensino fundamental da cidade de Matinhos (PR). MATERIAIS E MÉTODOS: Foram avaliados 126 professores (120 mulheres e seis homens, 38,6 ± 9 anos) por meio de um questionário contendo dados gerais e ocupacionais e pelo questionário nórdico. Análises estatísticas univariadas desses questionários foram realizadas com o teste qui-quadrado. Um modelo linear logístico múltiplo foi estabelecido para predizer as variáveis respostas do questionário nórdico a partir das variáveis independentes do questionário de dados gerais e ocupacionais. RESULTADOS: A presença de dor não indicou associação significativa com a idade, realização de atividade física, número de alunos por classe e tempo de profissão (p > 0,05), relacionou-se apenas com o número de classes que lecionavam (p = 0,02). Porém, a presença de dor nos últimos 12 meses teve relação com o impedimento de realizar atividade nos últimos 12 meses e a procura por algum profissional da saúde (p > 0,05). Dos participantes, 95,2% apresentaram algum sintoma osteomuscular. As áreas mais atingidas foram lombar (51,5%), região dorsal (49,2%), ombro (49,2%) e pescoço (47,6%). CONCLUSÕES: Os professores apresentaram elevada prevalência de sintomas osteomusculares, especialmente na lombar, nos ombros e na região dorsal, os quais, por sua vez, provocaram o impedimento de realizar atividades cotidianas.


INTRODUCTION: To investigate the etiology of musculoskeletal symptoms in teachers, studies have addressed the relationship between teaching and possible peculiarities of the profession that can lead to physical illness of teachers. OBJECTIVE: To identify the occurrence of musculoskeletal symptoms of elementary school teachers in Matinhos (PR). MATERIALS AND METHODS: It was evaluated 126 teachers (120 women and 6 six men, 38.6 ± 9 years old) through a questionnaire containing an inventory for general and occupational data and the Nordic questionnaire. In the statistical analysis we compared independent variables from inventory for general and occupational data dependent with dependent variables of Nordic questionnaire by multivariate logistic regression analysis and chi-squared test to compare (p < 0.05). RESULTS: The presence of pain did not indicate relationship with age, physical activity, number of students per class or time of profession (p > 0.05), although the number of classes per teacher was significant (p = 0.02). However, the pain in the last 12 months was related to prevent activities in the last 12 months and also to assistance by health professional (p > 0.05). Musculoskeletal symptoms occurred in 95.2% of participants. The most affected regions were: lower back (51.5%), chest (49.2%), shoulders (49.2%) and neck (47.6%). CONCLUSION: Thus, teachers presented high prevalence of musculoskeletal symptoms especially in lower back, chest and shoulders, and these prevented daily activities.


Subject(s)
Cumulative Trauma Disorders , Faculty , Musculoskeletal Abnormalities , Occupational Diseases , Occupational Health
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