ABSTRACT
The prognosis of diffuse panbronchiolitis (DPB) has been remarkably improved after the development of low-dose erythromycin therapy, possibly due to anti-inflammatory rather than anti-infective mechanisms. Interestingly, DPB associated with lung cancer is quite rare. Here, we report an autopsy case of DPB who developed lung cancer after a long successful therapy with low-dose erythromycin.
Subject(s)
Bronchiolitis/complications , Lung Neoplasms/complications , Adenocarcinoma/complications , Adenocarcinoma/diagnosis , Aged , Anti-Bacterial Agents/therapeutic use , Autopsy , Bronchiolitis/diagnosis , Bronchiolitis/drug therapy , Erythromycin/therapeutic use , Female , Humans , Lung Neoplasms/diagnosis , PrognosisABSTRACT
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. While an elevated incidence of lung cancer has been observed in patients with RA or psoriasis, there has been no report of psoriatic arthritis associated with lung cancer. We here report the first case of psoriatic arthritis which developed lung cancer. In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.
Subject(s)
Arthritis, Psoriatic/complications , Carcinoma, Bronchogenic/etiology , Lung Neoplasms/etiology , Aged , Arthritis, Psoriatic/diagnostic imaging , Arthritis, Psoriatic/drug therapy , Biopsy , Carcinoma, Bronchogenic/diagnostic imaging , Carcinoma, Bronchogenic/pathology , Fatal Outcome , Humans , Immunosuppressive Agents/therapeutic use , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/pathology , Male , Methotrexate/therapeutic use , Risk Factors , Smoking/adverse effects , Tomography, X-Ray ComputedABSTRACT
There are no guidelines regarding the treatment of pulmonary sarcoidosis. Generally, oral corticosteroids are considered the first-line treatment for symptomatic patients with pulmonary sarcoidosis. We report here two Japanese cases with pulmonary sarcoidosis who demonstrated sequential evolution from radiographic stage I to III within five years. Although these two cases had no symptoms, persistent, progressive pulmonary involvements were observed on chest X-ray. Considering the effectiveness of corticosteroids on patients with radiographic type II or III sarcoidosis reported by the British Thoracic Society, corticosteroid therapy might be a choice even in asymptomatic cases, if they demonstrate developing pulmonary involvement.
