1.
Adv Prostaglandin Thromboxane Res
; 8: 1669-73, 1980.
Article
in English
| MEDLINE
| ID: mdl-7377015
Subject(s)
Antibody Formation/drug effects , Immunologic Memory/drug effects , Prostaglandins/pharmacology , Spleen/immunology , Animals , Arachidonic Acids/pharmacology , Cells, Cultured , Erythrocytes/immunology , Immune Tolerance/drug effects , Mice , Prostaglandins E/pharmacology , Prostaglandins F/pharmacology
2.
Res Commun Chem Pathol Pharmacol
; 19(1): 141-9, 1978 Jan.
Article
in English
| MEDLINE
| ID: mdl-625583
ABSTRACT
Levamisole, L-2,3,5,6-tetrahydro-6-phenylimidazo-(2,1-b)-thiazole-hydrocholoride at various concentrations (2.5 to 40 microgram) added to platelet rich plasma inhibited aggregation of platelets. The 50% inhibition concentrations (IC50) of levamisole in platelet aggregation induced by hydrogen peroixde (9.4 x 10(-1) mM), epinephrine (1.0 x 10(-1) micrometer), endoperoxide-analog (2.9 x 10(-1) micrometer) and arachidonic acid (3.3 micrometer) were 11.0, 8.0, 11.5 and 16.0 microgram/test, respectively. It is suggested that levamisole like imidazole inhibit platelet aggregation and this factor should be considered in the administration of levamisole, especially in cardiovascular diseases.