ABSTRACT
PURPOSE: To evaluate the expected anticaries efficacy of a new dentifrice containing stannous fluoride as the anticaries agent and potassium nitrate as the antihypersensitivity agent using a series of laboratory and animal studies. METHODS: Four surrogate studies were performed in this assessment including fluoride uptake in sound enamel, enamel solubility reduction, fluoride bioavailability and animal caries. RESULTS: Each of these studies indicated the new dentifrice for hypersensitivity (Colgate Sensitive Maximum Strength) was effective in inhibiting the caries process. The data demonstrate that this new dentifrice is predicted to be highly effective against caries and equivalent to a positive control dentifrice.
Subject(s)
Cariostatic Agents/therapeutic use , Dental Caries/prevention & control , Dentifrices/therapeutic use , Dentin Sensitivity/prevention & control , Nitrates/therapeutic use , Potassium Compounds/therapeutic use , Tin Fluorides/therapeutic use , Acid Etching, Dental , Actinomyces viscosus/physiology , Animals , Biological Availability , Cariostatic Agents/administration & dosage , Cariostatic Agents/pharmacokinetics , Dental Caries/microbiology , Dental Enamel/drug effects , Dental Enamel Solubility/drug effects , Diet, Cariogenic , Disease Models, Animal , Humans , Nitrates/administration & dosage , Potassium Compounds/administration & dosage , Rats , Rats, Inbred Strains , Streptococcus sobrinus/physiology , Tin Fluorides/administration & dosage , Tin Fluorides/pharmacokineticsABSTRACT
PURPOSE: To review the published literature on clinical caries trials of fluoride dentifrices and to combine their results in order to evaluate the correlation between fluoride concentration in dentifrice formulations and their anticaries efficacy, i.e., the dose-response relationship. METHODS: All available dentifrice caries clinical trials reported in the literature of products having at least two fluoride concentrations greater than 0 ppm were reviewed, graphed and statistically analyzed. RESULTS: The evaluation supported a linear correlation between the fluoride concentration of dentifrices between 0 and 5000 ppm F and clinical caries efficacy.
