ABSTRACT
PURPOSE: We aimed to investigate the prognostic value of DNA index (DI) in children with precursor B cell acute lymphoblastic lymphoma (pre-B ALL). MATERIALS AND METHODS: From January 2003 to December 2014, 72 children diagnosed with pre-B ALL were analyzed. We analyzed the prognostic value of DI and its relations with other prognostic factors. RESULTS: The DI cut-point of 1.16 did not discriminate significantly the groups between high and low survivals (DI≥1.16 versus <1.16; 5-year OS, 90.5% vs. 82.8%, p=0.665). We explored the survivals according to the level of DI (<1.00, 1.00, 1.01-1.30, 1.31-1.60, 1.61-1.90, and >1.90), and the survival of children with a DI between 1.00-1.90 were significantly higher than that of children with DI of <1.00 or >1.90 (5-year OS, 90.6% vs. 50.0%, p<0.001). CONCLUSIONS: The DI of 1.16 was not a significant cut-point discriminating the risk group in children with pre-B ALL. However, the DI divided by specific ranges of values remained an independent prognostic factor. Further studies are warranted to re-evaluate the prognostic value and cut-point of DI in children treated with recent treatment protocols.
Subject(s)
DNA, Neoplasm/metabolism , Ploidies , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Adolescent , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cancer Care Facilities , Child , Child, Preschool , Cohort Studies , Cytogenetic Analysis , Diploidy , Female , Follow-Up Studies , Hospitals, University , Humans , Infant , Male , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism , Prognosis , Republic of Korea , Retrospective Studies , Risk , Survival AnalysisABSTRACT
We demonstrate a method for constructing bifunctional nanostructures, which conjugate biochemical and electrocatalytic activities, on glassy carbon surfaces by decorating the carbon surfaces with both biologically active glucose oxidases and size-monodisperse Pt nanoparticles (less than 2 nm in diameter) utilizing only a single dendrimer layer.
Subject(s)
Carbon/chemistry , Dendrimers/chemistry , Metal Nanoparticles/chemistry , Nanostructures/chemistry , Glucose Oxidase/metabolism , Platinum/chemistry , Polyamines/chemistry , Surface PropertiesABSTRACT
Rhodamine-based chemosensors 1 and 2 were synthesized and self-assembled onto glass surfaces for the selective fluorescent sensing of Pb(2+). The immobilized chemosensors showed fluorescent responses that were turned-on with Pb(2+) in CH(3)CN, selectively over various metal ions. The Pb(2+)-selective fluorescent switch of the immobilized chemosensors was also reversible, allowing for repeated use for Pb(2+) detection.
