The Moderating Effect of Resilience on Mental Health Deterioration among COVID-19 Survivors in a Mexican Sample.

Resilience has been reported to be a protective psychological variable of mental health; however, little is known about its role in COVID-19 survivors. Thus, in this study, we aimed to evaluate the levels of depression, anxiety, stress, traumatic impact, and resilience associated with COVID-19, as well as to investigate the role of resilience as a moderating variable. A sample of 253 participants responded to an online survey; all were previously diagnosed with COVID-19 by a nasopharyngeal swab RT-PCR test, were older than 18 years, and signed an informed consent form. Significant negative correlations were found between resilience and the mental health variables. Higher resilience was significantly related to a lower impact of the event, stress, anxiety, and depression when the number of symptoms was low. Only when the duration of COVID-19 was short and resilience levels were medium or high was psychological distress reduced. Moreover, resilience moderated the effects of COVID-19 on mental health, even if a relapse occurred. The results emphasize the need for interdisciplinary interventions aimed at providing COVID-19 patients with psychological and social resources to cope with the disease, as well as with probable relapses.

Psychological responses to COVID-19 in a Mexican population: an exploratory study during second and third phases.

This work constitutes an exploratory study during the second and third phases of COVID-19 in Mexico, characterized by local transmission and untraceable cases, respectively, with an incidental sample of 666 participants. The 21-item Depression Anxiety Stress Scale was used to assess depression, anxiety and stress associated to COVID-19. Additionally, the Impact of the Event Scale-Revised was applied to assess the impact of the event, and the 10-item Connor-Davidson Resilience Scale was employed to assess resilience. Participants' levels of traumatic impact (21.7%), severe depression (7%), severe anxiety (9.4%) and severe stress (5.4%) were revealed to be lower than other populations. Comparison of means and effect size η2p of the data shows that women and young people (18-39 years) suffer the greatest negative effects. Individuals with higher levels of resilience experience fewer psychological consequences confirming its importance in the face of the adversities. These findings provide valuable information on the impact of COVID-19 pandemic in the Mexican population, allowing a comparative analysis at an international level which can be helpful in the development of appropriate sanitary policies.

Impacto psicológico de la pandemia COVID-19 en cinco países de Latinoamérica / Psychological impact of the COVID-19 pandemic on five Latin American countries

Resumen Introducción: El distanciamiento social y la cuarentena han probado tener efectos negativos en la salud mental de las poblaciones, a saber: miedo, ansiedad, depresión y sintomatología de estrés postraumático. La resiliencia emerge como variable amortiguadora del impacto. El objetivo del estudio fue comparar el impacto psicológico del COVID-19 en varios países latinoamericanos. Método: se obtuvo una muestra de 1184 participantes de México, Cuba, Chile, Colombia y Guatemala; cuya edad osciló entre 18 y 83 años (M = 38.78, DT = 13.81). Se aplicó una encuesta sobre síntomas médicos asociados al COVID-19 con tres instrumentos para evaluar: (1) síntomas de depresión, ansiedad y estrés, (2) impacto del evento y (3) resiliencia. Resultados: Las personas más jóvenes, con mayor cantidad de síntomas médicos y con mayores puntajes de impacto del evento tienden a presentar mayor sintomatología depresiva, ansiosa y estrés, siendo el impacto del evento el predictor más determinante. La resiliencia fue el predictor protector contra la depresión, ansiedad y estrés. Conclusiones: Los resultados muestran las diferencias en la respuesta psicológica ante la pandemia del COVID-19 en cada país, y sugieren la necesidad del desarrollo de políticas públicas enfocadas en la prevención y la promoción de la salud integral ante emergencias sanitarias.

Abstract Introduction: Social distancing and quarantine have proven to have negative effects on the mental health of populations, namely fear, anxiety, depression and post-traumatic stress symptoms. Resilience emerges as a buffering variable for such impact. The objective of this study was to compare the psychological impact of COVID-19 in several Latin American countries. Method: A sample of 1184 participants from Mexico, Cuba, Chile, Colombia and Guatemala was obtained; whose age ranged from 18 to 83 years old (M = 38.78, SD = 13.81). A survey on medical symptoms associated with COVID-19 and three instruments to evaluate: (1) depression, anxiety and stress, (2) impact of the event and (3) resilience were administered. Results: Younger people, with more symptoms associated with COVID-19 and those who reported higher scores of impact of event tended to present greater depressive, anxious and stress symptomatology. The impact of the event was the most determinant predictor. Resilience was protective against the impact of event, depression, anxiety and stress. Conclusions: The results show the differences in the psychological response to COVID-19 in each country and suggesting the need to develop public policies focused on prevention and promotion of integral health when facing sanitary emergencies.

Precautionary Behaviors during the Second and Third Phases of the COVID-19 Pandemic: Comparative Study in the Latin American Population.

The population's behavioral responses to containment and precautionary measures during the COVID-19 pandemic have played a fundamental role in controlling the contagion. A comparative analysis of precautionary behaviors in the region was carried out. A total of 1184 people from Mexico, Colombia, Chile, Cuba, and Guatemala participated through an online survey containing a questionnaire on sociodemographic factors, precautionary behaviors, information about COVID-19, concerns, maintenance of confinement, and medical symptoms associated with COVID-19. Cubans reported the highest scores for information about COVID-19. Colombians reported less frequent usage of precautionary measures (e.g., use of masks), but greater adherence to confinement recommendations in general, in contrast to the low levels of these behaviors in Guatemalans. Chileans reported greater pandemic-related concerns and the highest number of medical symptoms associated with COVID-19. These findings allow a partial characterization of the Latin American population's responses during the second and third phases of the COVID-19 pandemic and highlight the importance of designing and managing public health policies according to the circumstances of each population when facing pandemics.

Prenatal Alcohol Exposure in Rats Diminishes Postnatal Cxcl16 Chemokine Ligand Brain Expression.

Maternal ethanol consumption during pregnancy is one of the main causes of Neurodevelopmental disorders (NDD). Prenatal alcohol exposure (PAE) produces several adverse manifestations. Even low or moderate intake has been associated with long-lasting behavioral and cognitive impairment in offspring. In this study we examined the gene expression profile in the rat nucleus accumbens using microarrays, comparing animals exposed prenatally to ethanol and controls. Microarray gene expression showed an overall downward regulatory effect of PAE. Gene cluster analysis reveals that the gene groups most affected are related to transcription regulation, transcription factors and homeobox genes. We focus on the expression of the C-X-C motif chemokine ligand 16 (Cxcl16) which was differentially expressed. There is a significant reduction in the expression of this chemokine throughout the brain under PAE conditions, evidenced here by quantitative polymerase chain reaction qPCR and immunohistochemistry. Chemokines are involved in neuroprotection and implicated in alcohol-induced brain damage and neuroinflammation in the developing central nervous system (CNS), therefore, the significance of the overall decrease in Cxcl16 expression in the brain as a consequence of PAE may reflect a reduced ability in neuroprotection against subsequent conditions, such as excitotoxic damage, inflammatory processes or even hypoxic-ischemic insult.

Comparison of subjective health between personality prototypes extracted from general population of Mexico / Comparação da saúde subjetiva entre protótipos de personalidade em população geral do México / Comparación de la salud subjetiva entre prototipos de personalidad recuperados en población general de México

Abstract The objective of this study was to extract personality prototypes from general population of Mexico and to compare subjective health indicators between these prototypes. Participants were 994 individuals (aged 14 to 63 years). Five personality traits (Neuroticism, Extraversion, Openness, Conscientiousness, and Agreeableness) were assessed with the NEO-FFI. Subjective indicators of health (self-rated health and psychological distress) were assessed with a question regarding health status and the GHQ-12. To verify the consistency of the prototypes, the sample was divided into two age groups, young (14 to 25 years) and mature (26 to 63 years.). Three stable prototypes were recovered from both groups. Resilient individuals (low neuroticism and high in other traits) had the best subjective health; the Non-Resilient individuals (high neuroticism and low in other traits) had the worst subjective health; and Self-Disciplined individuals (high conscientiousness and medium scores in other traits) were in the middle of these extremes in subjective health. Self-discipline and resilience were most discriminative in terms of subjective health. Findings are discussed in terms of the generalization of prototypes across cultures.

Resumo O objetivo deste estudo foi obter protótipos da personalidade em população geral do México e comparar a saúde subjetiva entre eles. No total, participaram 994 indivíduos de 14 a 63 anos. Avaliaram-se cinco traços de personalidade (extroversão, neuroticismo, abertura à experiência, conscienciosidade e amabilidade) com o NEO-FFI, e a saúde subjetiva com o GHQ-12, e uma pergunta sobre o estado de saúde. Para corroborar a consistência dos protótipos, dividiu-se a amostra em dois grupos de idade: jovem (de 14 a 25 anos) e adulto (de 26 a 63 anos). Como resultado, obtiveram-se três protótipos em ambos os grupos: as pessoas resilientes -baixo neuroticismo e alto nos demais traços-, os que tiveram a melhor saúde subjetiva; as não resilientes -alto neuroticismo e baixo no restante dos traços-, que apresentaram a pior saúde subjetiva, e as pessoas disciplinadas -alto em conscienciosidade e média nos outros traços-, que apresentaram uma saúde subjetiva intermediária em comparação com os outros protótipos. Finalmente, a autodisciplina e a resiliência foram os traços que melhor discriminaram a boa saúde. Os achados são discutidos em termos da generalização de protótipos através de culturas.

Resumen El objetivo de este estudio fue obtener prototipos de personalidad en población general de México y comparar la salud subjetiva entre ellos. En total, participaron 994 individuos de 14 a 63 años de edad. Se evaluaron cinco rasgos de personalidad (Neuroticismo, Extraversión, Apertura, Responsabilidad y Amabilidad) con el NEO-FFI, y la salud subjetiva con el GHQ-12 y una pregunta sobre el estado de salud. Para corroborar la consistencia de los prototipos se dividió la muestra en dos grupos de edad: joven (de 14 a 25 años) y maduro (de 26 a 63 años). Y como resultado se recuperaron tres prototipos en ambos grupos: las personas Resilientes -bajo neuroticismo y alto en el resto de los rasgos-, quienes tuvieron la mejor salud subjetiva; las No-Resilientes -alto neuroticismo y bajo en el resto de los rasgos-, que presentaron la peor salud subjetiva; y las personas Disciplinadas -alto en responsabilidad y promedio en los otros rasgos-, que presentaron una salud subjetiva intermedia en comparación con los otros prototipos. Finalmente, la autodisciplina y la resiliencia fueron los rasgos que discriminaron mejor la buena salud. Los hallazgos se discuten en términos de la generalización de prototipos a través de culturas.