ABSTRACT
BACKGROUND: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. AIM: To investigate the gender difference of BrS in Han Chinese. DESIGN: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. METHODS: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. RESULTS: The percentage of family history of SCD in females was slightly higher (31.3% vs. 15%, P = 0.15). Females exhibited longer QTc (457.8 ± 33.0 vs. 429.5 ± 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P = 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 ± 26.8 vs. 104.8 ± 15.3 ms, P = 0.02) and QTc (442.5 ± 57.4 vs. 422.9 ± 28.8 ms, P = 0.02). Males with syncope exhibited longer PR interval (181.2 ± 33.7 vs. 165.7 ± 27.1 ms, P = 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 ± 9.6 vs. 82.2 ± 16.3 bpm, P = 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. CONCLUSION: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.
Subject(s)
Brugada Syndrome/genetics , Death, Sudden, Cardiac/epidemiology , Long QT Syndrome/epidemiology , NAV1.5 Voltage-Gated Sodium Channel/genetics , Sex Factors , Syncope/etiology , Adult , Brugada Syndrome/complications , Brugada Syndrome/physiopathology , Death, Sudden, Cardiac/etiology , Electrocardiography , Female , Humans , Long QT Syndrome/etiology , Male , Middle Aged , Mutation , Registries , Risk Assessment , Sex Distribution , Syncope/epidemiology , Taiwan/epidemiologyABSTRACT
OBJECTIVE: To evaluate the effect of lesion length on in-stent restenosis (ISR) of vertebral artery (VA) origin stenting. METHODS: We retrospectively analyzed the medical and radiological records of patients receiving VA origin stenting from March 1999 to June 2005. They were subdivided according to lesion length. ISR was defined as >50% diameter narrowing in stent. RESULTS: Eighty symptomatic patients (64 male, mean age 72 years) with 90 lesions treated with balloon expandable tubular coronary stents were enrolled. There were 34 patients with 38 short lesions (length
Subject(s)
Stents , Vertebral Artery , Vertebrobasilar Insufficiency/therapy , Aged , Aged, 80 and over , Angioplasty, Balloon , Constriction, Pathologic , Female , Humans , Male , Middle Aged , Radiography , Recurrence , Vertebral Artery/diagnostic imaging , Vertebral Artery/pathology , Vertebrobasilar Insufficiency/diagnostic imaging , Vertebrobasilar Insufficiency/pathologyABSTRACT
A 66-year-old male presented with keratosis lichenoides chronica after a presumed drug-induced erythroderma. After resolution of the erythroderma, slightly scaly erythematous and violaceous papules in a reticular arrangement over the trunk and limbs developed in association with hoarseness, palmoplantar keratoderma, onycholysis and subungual keratosis. Histology from a lichenoid lesion showed pseudo-epitheliomatous hyperplasia, hyperorthokeratosis, parakeratosis, dyskeratosis, neutrophil exocytosis and focal vacuolar degeneration of the basal layer of the epidermis. There was a band-like chronic inflammatory infiltrate in the upper dermis. The skin improved with prednisone 40 mg/day for 15 days, leaving atrophic hypopigmented scars. A diagnosis of keratosis lichenoides chronica was made.
Subject(s)
Dermatitis, Exfoliative/complications , Keratosis/pathology , Lichen Planus/pathology , Aged , Biopsy, Needle , Dermatitis, Exfoliative/diagnosis , Follow-Up Studies , Humans , Keratosis/drug therapy , Keratosis/etiology , Lichen Planus/drug therapy , Lichen Planus/etiology , Male , Prednisone/administration & dosageABSTRACT
The neurocutaneous melanosis is a rare syndrome in which the congenital melanocytic nevi and excessive melanosis are the main features. The syndrome seems to be a morphogenesis error of the embryonic neuroectoderm. A clinical case with necroscopy in a 19 year-old man who had developed malign melanoma in his central nervous system is reported.
Subject(s)
Central Nervous System Neoplasms/diagnosis , Melanoma/diagnosis , Neoplasms, Multiple Primary/diagnosis , Skin Neoplasms/diagnosis , Adult , Humans , Male , Nevus, Pigmented/diagnosis , SyndromeABSTRACT
A melanose neurocutânea é uma síndrome rara caracterizada por nervos melanocíticos congênitos gigantes e excessiva melanose da leptomeninge. A síndrome parece representar um erro na morfogênese do neuroectoderma embrionário. Os autores apresentam o caso e necropsia de um paciente masculino de 19 anos que desenvolveu melanoma maligno do sistema nervoso central.
Subject(s)
Humans , Male , Adult , Skin Neoplasms/diagnosis , Central Nervous System Neoplasms/diagnosis , Melanoma/diagnosis , Nevus, Pigmented/diagnosis , SyndromeABSTRACT
A high-performance double-crystal-monochromator soft X-ray (DCMSX) beamline has been constructed at the Synchrotron Radiation Research Center (SRRC). This beamline delivers monochromatic photon beams with energies from 1 to 9 keV and a resolving power (E/DeltaE) of up to 7000. This beamline provides users with an opportunity to study many important materials, such as high-T(c) superconductors, magnetic materials, catalysts, super-alloy compounds etc. Excellent EXAFS and NEXFS spectra have been routinely obtained from this beamline. Several interesting research projects are currently being conducted at this beamline. All the results show that this beamline has been constructed to meet its design goals.
