[Assisted reproductive technologies with sperm donation]. / Assistance médicale à la procréation avec don de spermatozoïdes.

INTRODUCTION: The purpose of this review is to relate to the operating rules of CECOS in France and the legal, medical and ethical issues raised by sperm donation. MATERIAL AND METHODS: Review of articles and consensus conferences on this subject published in Medline (PubMed) selected from 1973 and 2011 according to their relevance and Acts recorded on official legislative French websites. RESULTS: The operating rules of CECOS were established by the Act of July 29, 2004, revised 6 August 2004 and July 7, 2011. Of the 21,759 children born of ART in France in 2009, 5.1% are from a sperm donation. From 1973 to 2006, 44,045 children are born after a sperm donation. Between 1973 and 2006, 16,971 donors are presented in the CECOS and only 10,347 donors have completely made their donation process. The main indication for use of donor sperm (75% of applications) is represented by men of infertile couples with nonobstructive azoospermia, the second indication is infertile men with oligospermia. In azoospermia, the application is usually performed after failure of testicular or epididymal surgical specimen. In oligozoospermia, claims made most often after several failures of intraconjugal ART. CONCLUSION: Many questions are still present around the conception of children by sperm donation. The legitimacy of maintaining anonymity in the gift remains widely debated.

[1998 french results on medically assisted reproduction with gamete cryopreservation and donation. French Federation of CECOS]. / Bilan français 1998 de l'assistance médicale à la procréation avec tiers donneur et de l'autoconservation. Fédération Française des CECOS.

During the year 1998, the French Federation of CECOS recorded the results of the 23 CECOS centers and IFRAERES in Toulouse. 1,573 first demands of procreation with sperm donors were registed (versus 1,620 in 1997). From 9,339 cycles (AID or IVFD), 1351 pregnancies were obtained, scoring the identical amount in terms of pregnancies as in 1997 but with less 9% in terms of cycles. Ovulation monitoring and IVFD are more and more used. The analysis of the 1,169 deliveries of the 1997 pregnancies shows a malformation rate of 1.8%. 658 male volunteers came forward as semen donors (51% more than in 1997). In gamete autocryopreservation, the number of semen preservation is globaly increasing (16% more than in 1997), mainly due to the capacity of a better reutilisation with ICSI. At the end of 1998, 15 Centres was looking after 21,222 cryopreserved embryos, 25% in the aim of a near future use.