ABSTRACT
Exoerythrocytic (EE) schizonts of Plasmodium fragile were found in liver tissue acquired 7, 8, 9, and 10 days following inoculation of Macaca mulatta monkeys with sporozoites from Anopheles balabacensis balabacensis mosquitoes. There was little to distinguish the EE bodies of P. fragile from EE bodies of many of the other species of primate malaria.
Subject(s)
Malaria/parasitology , Plasmodium/growth & development , Animals , Anopheles/parasitology , Haplorhini , Liver/parasitology , Macaca mulatta , Plasmodium/cytologySubject(s)
Anopheles , Fluorescent Antibody Technique , Plasmodium/immunology , Animals , Haplorhini , Immunization , Macaca , Malaria/immunology , Methods , Plasmodium/cytologySubject(s)
Liver/microbiology , Malaria/microbiology , Plasmodium vivax/growth & development , Animals , Anopheles , Biopsy , Disease Models, Animal , Haplorhini , Histological Techniques , Liver/pathology , Malaria/pathology , Plasmodium vivax/isolation & purification , Salivary Glands/microbiology , Time FactorsSubject(s)
Malaria/veterinary , Monkey Diseases/pathology , Plasmodium/classification , Animals , Anopheles , Cell Nucleus , Cytoplasm , Haplorhini , Hominidae , Inclusion Bodies , Injections, Intravenous , Insect Vectors , Liver/pathology , Malaria/pathology , Plasmodium/anatomy & histology , Plasmodium/cytology , Protozoan Infections/etiology , Species Specificity , Time FactorsABSTRACT
The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of EE stages. The usefulness of RC-12 for effecting radical cures is, however, still open to doubt.
